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1. Characterization of hERG K⁺ channel inhibition by the new class III antiarrhythmic drug cavutilide

   Cavutilide (niferidil, refralon) is a new class III antiarrhythmic drug which effectively terminates persistent atrial fibrillation (AF; 84.6% of...

   Denis V. Abramochkin, Oksana B. Pustovit, ... Tatiana Nesterova in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 15 January 2024
   

2. The Dependence of the Electrophysiological Effects of Class III Antiarrhythmic Drug Refralon on the Frequency of Myocardium Activation

   We studied the frequency dependence of the effects of the novel Russian class III antiarrhythmic drug refralon on the duration of action potentials...

   D. V. Abramochkin, O. B. Pustovit, ... V. S. Kuzmin in Bulletin of Experimental Biology and Medicine

   Article 01 March 2023

3. Antiarrhythmic Drugs

   Jordi Heijman, Dobromir Dobrev in Encyclopedia of Molecular Pharmacology

   Reference work entry 2021
   

4. Population pharmacokinetic/pharmacodynamic modeling of nifekalant injection with varies dosing plan in Chinese volunteers: a randomized, blind, placebo-controlled study

   Nifekalant hydrochloride is a class III antiarrhythmic agent which could increase the duration of the action potential and the effective refractory...

   Juanjuan Jiang, Li Xu, ... Lei Tian in Journal of Pharmacokinetics and Pharmacodynamics

   Article 11 August 2023
   

5. Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction

   We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50%...

   A. A. Spasov, A. F. Kucheryavenko, ... V. N. Pavlov in Bulletin of Experimental Biology and Medicine

   Article 10 January 2022

6. The Short QT Syndrome

   The short QT syndrome (SQTS) is characterised by abbreviated QT intervals on the electrocardiogram and by an increased risk of atrial and ventricular...

   Jules C. Hancox, Mark J. McPate, ... Henggui Zhang in Heart Rate and Rhythm

   Chapter 2023
   

7. Antiarrhythmic Drugs

   Jordi Heijman, Dobromir Dobrev in Encyclopedia of Molecular Pharmacology

   Living reference work entry 2020
   

8. Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus

   Purpose

   Imeglimin is the first in a new class of oral antidiabetic agents, the glimins, currently in development to improve glycemic control in...

   Julie Dubourg, Sandrine Perrimond-Dauchy, ... Pascale Fouqueray in European Journal of Clinical Pharmacology

   Article 18 June 2020
   

9. The Neuro-cardiac Axis in Arrhythmogenesis: Role and Impact of Autonomic Modulation

   The autonomic nervous system consisting of two limbs, the sympathetic and parasympathetic nervous system, plays a key role in the modulation of...

   Shui Hao Chin, G. André Ng in Heart Rate and Rhythm

   Chapter 2023
   

10. Zacopride stimulates 5-HT₄ serotonin receptors in the human atrium

    Zacopride (4-amino-5-chloro-2-methoxy-N-(quinuclidin-3-yl)-benzamide) is a potent agonist in human 5-HT ₄ serotonin receptors in vitro and in the...

    Joachim Neumann, Christin Hesse, ... Ulrich Gergs in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article Open access 01 April 2024
    

11. Treatment Planning for Atrial Fibrillation Using Patient-Specific Models Showing the Importance of Fibrillatory-Areas

    Computational models have made it possible to study the effect of fibrosis and scar on atrial fibrillation (AF) and plan future personalized...

    Roya Kamali, Karli Gillete, ... Ravi Ranjan in Annals of Biomedical Engineering

    Article 05 August 2022
    

12. Drugs Used in Cardiac Arrhythmias

    Cardiac arrhythmias range from the fast-beating tachyarrhythmias–which include atrial fibrillation, ventricular tachycardia, and fibrillation and the...

    Gerard Marshall Raj in Introduction to Basics of Pharmacology and Toxicology

    Chapter 2021
    

13. Drugs Acting on Renal and Cardiovascular Function

    Cardiovascular medications play a crucial role in medical practice by influencing the functionality of the heart and blood vessels. These medications...

    Raja Chakraverty, Tatini Debnath in Essentials of Pharmacodynamics and Drug Action

    Chapter 2024
    

14. Polypharmacology in Clinical Applications: Cardiovascular Polypharmacology

    Cardiovascular disease (CVD) is a class of disorders of the heart and blood vessels and the leading cause of death...

    Zhiguo Wang, Baofeng Yang in Polypharmacology

    Chapter 2022
    

15. Influence of Kv11.1 (hERG1) K⁺ channel expression on DNA damage induced by the genotoxic agent methyl methanesulfonate

    Besides their crucial role in cell electrogenesis and maintenance of basal membrane potential, the voltage-dependent K ⁺ channel Kv11.1/hERG1 shows an...

    Sara Fernández-Villabrille, Enol Álvarez-González, ... Luisa María Sierra in Pflügers Archiv - European Journal of Physiology

    Article 15 January 2021
    

16. Drug repurposing: a retrospective revolution in breast cancer medicine

    Breast cancer is a complex disease involving numerous pathways, making effective treatment quite challenging. Among the current scenario, drug...

    Dave Shivani, Patel Misari, ... Shah Jignesh in Discover Medicine

    Article Open access 12 July 2024
    

17. Kv11.1 (hERG1) Channels and Cardiac Arrhythmia

    The rapid delayed rectifier K+ current (IKr) is one of several outward currents that mediate repolarization of cardiac action potentials in humans...

    Michael C. Sanguinetti in Heart Rate and Rhythm

    Chapter 2023
    

18. Drug-Induced Tremors

    Drug-induced tremors are common in clinical practice, but often underrecognized or misdiagnosed. There are a myriad of drugs that can cause or...

    Jessica McClard, Colin McLeod, John C. Morgan in Mechanisms and Emerging Therapies in Tremor Disorders

    Chapter 2023
    

19. Impact of Space Pharmaceuticals on Cardiovascular System

    After half a century full of exciting mix of space flight success and failures, space scientists, governments, and entrepreneurs have learned a...

    Rakesh Sharma, Madhvi Trivedi, Arvind Trivedi in Handbook of Space Pharmaceuticals

    Living reference work entry 2022
    

20. Impact of Space Pharmaceuticals on Cardiovascular System

    After half a century full of exciting mix of space flight success and failures, space scientists, governments, and entrepreneurs have learned a...

    Rakesh Sharma, Madhvi Trivedi, Arvind Trivedi in Handbook of Space Pharmaceuticals

    Reference work entry 2022