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Circulating tumour cells in gastrointestinal cancers: food for thought?
Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant...
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Biology, vulnerabilities and clinical applications of circulating tumour cells
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from...
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Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention
Comprehensive tumour characterisation is indispensable for patients to receive targeted therapy. The use of liquid biopsy, particularly circulating...
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Incidental finding of leukaemia in circulating tumour DNA— the importance of a molecular tumour board
As the use of liquid biopsies are increasing across multiple indications in cancer medicine, the detection of incidental findings on circulating...
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Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenoty**
BackgroundCirculating tumour cells (CTCs) are a potential cancer biomarker, but current methods of CTC analysis at single-cell resolution are...
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New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells
Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung...
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Extruded small extracellular vesicles: splinters of circulating tumour cells may promote cancer metastasis?
We speculate ruptured circulating tumour cells (CTC) in capillaries could release a large number of small extracellular vesicle-like vesicles, namely...
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Circulating tumour cells and PD-L1-positive small extracellular vesicles: the liquid biopsy combination for prognostic information in patients with metastatic non-small cell lung cancer
BackgroundCirculating tumour cells (CTCs), circulating tumour DNA (ctDNA), and extracellular vesicles (EVs) are minimally invasive liquid biopsy...
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Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma
Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths...
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Circulating tumour cells are associated with histopathological growth patterns of colorectal cancer liver metastases
Histopathological Growth Patterns (HGPs) have prognostic and predictive value in patients with Colorectal Liver Metastases (CRLM). This study...
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Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value
BackgroundCirculating tumour cells (CTCs) are mainly enriched based on the epithelial cell adhesion molecule (EpCAM). Although it was shown that an...
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Circulating tumour cell isolation, analysis and clinical application
BackgroundCirculating tumour cells (CTCs) are cancer cells that circulate in the bloodstream after being shed from solid tumours. They can lead to...
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Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade
Metastasis formation is the main cause of cancer-related death in patients with solid tumours. At the beginning of this process, cancer cells escape...
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Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer
IntroductionSmall cell lung cancer (SCLC) is an aggressive malignancy with no established biomarkers. Schlafen 11(SLFN11), a DNA/RNA helicase that...
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Circulating tumour cells in the -omics era: how far are we from achieving the ‘singularity’?
Over the past decade, cancer diagnosis has expanded to include liquid biopsies in addition to tissue biopsies. Liquid biopsies can result in earlier...
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Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
BackgroundDetection of circulating tumour DNA (ctDNA) in biological fluids is a minimally invasive alternative to tissue biopsy for therapy...
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Dissecting the Molecular Profiles of Circulating Tumor Cells in Models of Breast and Prostate Cancers
The presence or absence of circulating tumour cells in breast and prostate cancer patients is predictive of outcome. The molecular information...
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Application of circulating tumour cells to predict response to treatment in head and neck cancer
BackgroundLocal recurrence and metastasis remain the major causes of death in head and neck cancer (HNC) patients. Circulating tumour cells (CTCs)...
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Circulating tumour mutation detection in triple-negative breast cancer as an adjunct to tissue response assessment
Circulating tumour DNA (ctDNA) detection via liquid biopsy is an emerging alternative to tissue biopsy, but its potential in treatment response...
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Fluid-Dynamic Culture of Tumour and Immune Cells for More Predictive Infiltration Studies and Immunotherapy Drug Screening
Immunotherapies represent one of the current most promising challenges in cancer treatment. They are based on the boost of natural immune responses,...