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Epigenetic Chemicals
Epigenetic chemicals are chemical substances that exert their toxicity on individual inheritance through the epigenetic mechanism. In this chapter,...
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Safe Chemicals/REACH
Regulation (EC) No. 1907/2006 on Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) initiated a significant change in the...
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Pervasive environmental chemicals impair oligodendrocyte development
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as their development extends...
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Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence
Purpose of ReviewExposure to many synthetic chemicals has been linked to a variety of adverse human health effects, including autoimmune diseases. In...
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Expanded Toxicological Mechanisms of Chemicals
In this chapter, we show the perspective of the following chapters, comparing them to the general textbook of Toxicology. It is emphasized that...
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Environmental Chemicals as Plasticity Disruptors
The organism has plasticity consisting of several plasticities for homeostasis. In this chapter, developmental plasticity is introduced, particularly...
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Foreign Compounds: Foods, Drugs, Chemicals, and Lifestyles
Foods are substances that contain essential nutrients such as proteins, carbohydrates...
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Melanocytotoxic chemicals and their toxic mechanisms
Melanocyte cell death can lead to various melanocyte-related skin diseases including vitiligo and leukoderma. Melanocytotoxic chemicals are one of...
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Toward the Integrated Health Risk Assessment of Chemicals
In previous chapters, there are chemicals categorized as carcinogenic, endocrine-disrupting, and nano-size substances. Estimating the safe dose of...
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Health Risk Assessment of Environmental Chemicals Pre-Emptive and Integrated Approaches
This book presents the frontier research of toxicology and health risk assessment of chemicals. First, it provides an overview of the current methods...
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The Safe Dose in the Utilization of Chemicals
The dose responseDose response of chemicals is fundamental in estimating the safe doseSafe dose in their usage. In this chapter, it is shown that...
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A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico
To initiate skin sensitization, haptens react with endogenous proteins. During this process, skin sensitizers react with small endogenous molecules...
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Chemicals and Their Interaction in the Aquaculture System
Aquaculture is well-acknowledged as one of the few options of food security and economic growth that contribute significantly at the global level....
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Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4
Early brain development depends on adequate transport of thyroid hormones (THs) from the maternal circulation to the fetus. To reach the fetal brain,...
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Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
In Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) the criterion for deciding the studies that must be performed is the...
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Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs
To meet the growing demand for developmental toxicity assessment of chemicals, New Approach Methodologies (NAMs) are needed. Previously, we developed...
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Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma
Purpose of ReviewPrenatal and childhood exposure to synthetic chemicals, such as phenols and phthalates, have been linked to asthma and allergy, but...
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Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions
Purpose of ReviewWe are continuously exposed to dynamic mixtures of airborne contaminants that vary by location. Understanding the compositional...
