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Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis
BackgroundAcute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no...
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rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis
Farber disease (FD) is a rare monogenic lysosomal storage disorder caused by mutations in ASAH1 that results in a deficiency of acid ceramidase...
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Bioinformatics Analysis of Functional SNPs in Human ASAH1 Gene Related to Farber Disease
AbstractFarber disease is a rare lysosomal storage disorder resulted from mutations in the ASAH1 gene codes acid ceramidase. The present study aimed...
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Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer
Recently, it has become clear that a prerequisite requirement for most cancer therapies is controlling the negative impact of the activity of...
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PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies
BackgroundBreast cancer mortality is principally due to recurrent disease that becomes resistant to therapy. We recently identified copy number (CN)...
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Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
AbstractMajor depressive disorder (MDD) is a very common, severe disease with a lifetime prevalence of ~ 10%. The pathogenesis of MDD is unknown and,...
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A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia
Adiponectin, encoded by ADIPOQ , is an insulin-sensitizing, anti-inflammatory, and renoprotective adipokine that activates receptors with intrinsic...
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ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants
BackgroundLeukodystrophies are the main subgroup of inherited CNS white matter disorders which cause significant mortality and morbidity in early...
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Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease
Glycosphingolipids (GSLs) are a diverse group of membrane components occurring mainly on the surfaces of mammalian cells. They and their metabolites...
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Functional roles of sphingolipids in immunity and their implication in disease
Sphingolipids, which are components of cellular membranes and organ tissues, can be synthesized or degraded to modulate cellular responses according...
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Manifold Roles of Ceramide Metabolism in Non-Alcoholic Fatty Liver Disease and Liver Cancer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder manifested in hepatic fat accumulation (hepatic steatosis) in the absence of heavy...
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Sphingolipid Metabolism in Cancer: Potential Therapeutic Target
Sphingolipids, particularly their two main bioactive metabolites ceramide and sphingosine-1-phosphate (S1P), play a key role in cancer death and...
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Sphingolipids in Adipose: Kin or Foe?
Obesity research has shifted in recent years to address not only the total amount of adipose tissue present in an individual but also to include...
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Lipidomics Analysis Reveals a Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats
Ceramide accumulation has been associated with ischemic stroke. Myriocin is an effective serine palmitoyltransferase (SPT) inhibitor that reduces...
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Genetic Tools for Studying the Roles of Sphingolipids in Viral Infections
Sphingolipids are a critical family of membrane lipids with diverse functions in eukaryotic cells, and a growing body of literature supports that...
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Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis
Lupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identified with a poor prognosis....
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Sphingosine 1-Phosphate Lyase in the Develo** and Injured Nervous System: a Dichotomy?
Sphingosine 1-phosphate lyase (SPL) is the terminal enzyme that controls the degradation of the bioactive lipid sphingosine 1-phosphate (S1P) within...
