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Hyperinsulinemic–Euglycemic Clamp in Conscious Rats Based on the Tail Artery and Vein Catheterization
Insulin sensitivity evaluation is very important in the management and investigation of type 1 diabetes. Hyperinsulinemic–euglycemic clamp (HEC) is...
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Protective Role of Endothelial SIRT1 in Deep Vein Thrombosis and Hypoxia-induced Endothelial Dysfunction Mediated by NF-κB Deacetylation
Venous hypoxia is considered as the major pathogenetic mechanism linking blood flow stagnancy with deep vein thrombosis (DVT). Our previous study...
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MicroRNA miR-133a-3p Facilitates Adrenergic Proarrhythmic Ectopy in Rat Pulmonary Vein Myocardium by Increasing cAMP Content
Cardiac-specific microRNA miR-133a-3p modulates adrenergic signaling. Adrenergic receptors and their intracellular pathways are the key players in...
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3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage
Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD)....
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In Vivo DYSF Gene Viral Delivery Provides a Histoprotective Effect in Skeletal Muscle Tissue in Dysferlin-Deficient Mice
We studied the effects of a dual-vector DYSF gene delivery system based on adeno-associated virus serotype 9 capsids on pathological manifestations...
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Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype
The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of...
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Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology
BackgroundAlzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive ability. Exosomes derived from...
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Expression patterns of sex steroid receptors in develo** mesonephros of the male mouse: three-dimensional analysis
The androgen pathway via androgen receptor (AR) has received the most attention for development of male reproductive tracts. The estrogen pathway...
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Experimental Substantiation of the Use of HIFU Technology in the Treatment of the Lower Limb Varicose Disease
We present here an experimental study demonstrating the action of noninvasive high-intensity focused ultrasound (HIFU) on vein walls in the treatment...
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Superoxide dismutase 1-modified dental pulp stem cells alleviate high-altitude pulmonary edema by inhibiting oxidative stress through the Nrf2/HO-1 pathway
High-altitude pulmonary edema (HAPE) is a deadly form of altitude sickness, and there is no effective treatment for HAPE. Dental pulp stem cells...
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Influence of head-over-body and body-over-head posture on craniospinal, vascular, and abdominal pressures in an acute ovine in-vivo model
IntroductionOptimal shunt-based hydrocephalus treatments are heavily influenced by dynamic pressure behaviors between proximal and distal ends of...
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Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease
BackgroundAlbuminuria is a hallmark of diabetic kidney disease (DKD) that promotes its progression, leading to renal fibrosis. Renal macrophage...
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Rhombomere 7 r7
Rhombomere 7 is the origin of another vestibular nucleus—previously the spinal/inferior vestibular nucleus (see Chap. 5...
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TAPVR: Molecular Pathways and Animal Models
The venous pole of the heart where the pulmonary veinsPulmonaryvein will develop encompasses the sinus venosus and the atrium. In the fourth week of...
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tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis
It is well established that the synthesis of extracellular matrix (ECM) in mesangial cells is a major determinant of diabetic kidney disease (DKD)....
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Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging
BackgroundDetecting changes in pulsatile cerebrospinal fluid (CSF) flow may assist clinical management decisions, but spinal CSF flow is relatively...
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The influence of upright posture on craniospinal, arteriovenous, and abdominal pressures in a chronic ovine in-vivo trial
IntroductionMost investigations into postural influences on craniospinal and adjacent physiology have been performed in anesthetized animals. A...
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Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area
During spinal cord injury (SCI), the homeostasis of the cellular microenvironment in the injured area is seriously disrupted, which makes it...
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Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier
Many evidences show that exosomes play an important role in cancer development, invasion and metastasis. This study is based on the need to explore...
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Human Cardiac Development
Many aspects of heart development are topographically complex and require three-dimensional (3D) reconstruction to understand the pertinent...