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Zebrafish cardiac repolarization does not functionally depend on the expression of the hERG1b-like transcript
Zebrafish provide a translational model of human cardiac function. Their similar cardiac electrophysiology enables screening of human cardiac...
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The electrical restitution of the non-propagated cardiac ventricular action potential
Sudden changes in pacing cycle length are frequently associated with repolarization abnormalities initiating cardiac arrhythmias, and physiologists...
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Human Genetics of Cardiac Arrhythmias
Inherited forms of cardiac arrhythmias mostly are rare diseases (prevalence <1:2000) and considered to be either “primary electrical heart disorders”...
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Kv11.1 (hERG1) Channels and Cardiac Arrhythmia
The rapid delayed rectifier K+ current (IKr) is one of several outward currents that mediate repolarization of cardiac action potentials in humans...
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Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4...
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The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues
The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain...
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Velocity tracking of cardiac vector loops to identify signs of stress-induced ischaemia
Coronary artery disease (CAD) is among the leading causes of death worldwide. Initial studies require an electrocardiogram stress test often followed...
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Enlightening Cardiac Arrhythmia with Optogenetics
Cardiac optogenetics offers unprecedented opportunities to study the role of different cell populations in complex biological tissues, such as the...
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Cardiac Ion Channels and Heart Rate and Rhythm
The excitability of the heart is a prerequisite for its function as a pump distributing blood throughout the body. Initiated in the sinoatrial node,...
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Computational Cardiac Safety Testing
In recent years, computational cardiac electrophysiology simulations using mathematical models have begun to be used in industrial and regulatory...
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L-Type Ca2+ Channels and Cardiac Arrhythmias
L-type Ca2+ channels (LTCC) are voltage-gated Ca2+ channels with particular importance for cardiac function. They mediate Ca2+-induced Ca2+ release...
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Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats
Chronically stressed patients often have low vagal tone and increased levels of proinflammatory cytokines, which increase their risk for develo**...
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Genome Editing and Inherited Cardiac Arrhythmias
Inherited arrhythmic disorders are a group of heterogeneous diseases predisposing to life-threatening arrhythmias and sudden cardiac death. Their...
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Age-related increases in cardiac excitability, refractoriness and impulse conduction favor arrhythmogenesis in male rats
The effects of excitability, refractoriness, and impulse conduction have been independently related to enhanced arrhythmias in the aged myocardium in...
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Yohimbine Treatment Alleviates Cardiac Inflammation/Injury and Improves Cardiac Hemodynamics by Modulating Pro-Inflammatory and Oxidative Stress Indicators
Acute myocarditis, also known as myocardial inflammation, is a self-limited condition caused by systemic infection with cardiotropic pathogens,...
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Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction
Malignant ventricular arrhythmia (VA) after myocardial infarction (MI) is mainly caused by myocardial electrophysiological remodeling. Brahma-related...
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Hinokitiol for hypertensive emergencies: effects on peripheral resistance, cardiac load, baroreflex sensitivity, and electrolytes balance
Hinokitiol, a natural monoterpenoid, has been shown previously to possess a potent vasodilating activity in vitro in both control and hypertensive...
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Harnessing cell reprogramming for cardiac biological pacing
Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pum** and maintain life. Abnormal electrical...
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Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
The challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition,...
