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1. Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights

   Purpose

   Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to its high heterogeneity and aggressiveness. Recognizing the...

   Junyi Xu, Mingzhu Liu, ... ** Lu in Cellular Oncology

   Article 16 May 2024
   

2. Biosynthesis of Bacterial Polysaccharides

   The present chapter is devoted to biosynthesis pathways of various bacterial surface polysaccharides, including slime exopolysaccharides and capsular...

   Yuriy A. Knirel, Johanna J. Kenyon in Polysaccharides of Microbial Origin

   Reference work entry 2022
   

3. Adaptive Significance and Origin of Flavonoid Biosynthesis Genes in the Grain of Cultivated Cereals

   Abstract

   The majority of cultivated cereals including maize, rice, wheat, barley, oat and rye consist of numerous varieties lacking anthocyanin...

   A. N. Bulanov, A. V. Voylokov in Russian Journal of Genetics

   Article 01 February 2024
   

4. Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis

   Septic cardiomyopathy (SCM) is manifested by impairment of cardiac contractile function with myocardial mitochondrial dysregulation. Natural product,...

   Min Chen, Shanjiao Huang, ... Danjuan Liu in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 22 December 2023
   

5. Biosynthesis, Spectroscopic, and Antibacterial Investigations of Silver Nanoparticles

   Silver nanoparticles can be produced by an array of procedures, such as chemical, physical, and biological processes. The process of biosynthesis is...

   Helen Merina Albert, Kishore Mendam, ... M. P. Mallesh in Journal of Fluorescence

   Article 05 September 2023
   

6. Total syntheses of surugamides and thioamycolamides toward understanding their biosynthesis

   Peptidic natural products have received much attention as potential drug leads, and biosynthetic studies of peptidic natural products have...

   Takefumi Kuranaga in Journal of Natural Medicines

   Article Open access 08 November 2022
   

7. RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy

   Production of estradiol (E2) by the placenta during human pregnancy ensures successful maintenance of placental development and fetal growth by...

   Chao Tang, Meiyuan **, ... Qiang Xu in Experimental & Molecular Medicine

   Article Open access 18 January 2023
   

8. Lactobacillus gasseri LA39 promotes hepatic primary bile acid biosynthesis and intestinal secondary bile acid biotransformation

   A growing body of evidence has linked the gut microbiota to liver metabolism. The manipulation of intestinal microflora has been considered as a...

   Jun Hu, Qiliang Hou, ... **anghua Yan in Journal of Zhejiang University-SCIENCE B

   Article 15 August 2023

9. AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

   Background

   Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress...

   Hye ** Yun, Min Li, ... Jong-Ho Lee in Journal of Experimental & Clinical Cancer Research

   Article Open access 15 December 2023
   

10. Enzymes of Isoprenoid Biosynthesis and Control of Malarial Parasite Plasmodium falciparum

    There is high importance for the control of parasite Plasmodium falciparum which is responsible for causing malaria. Following the classical...

    Mohammad Othman Alkurbi, Saad Alghamdi, ... Qamre Aalm in Drug Targets for Plasmodium Falciparum: Historic to Future Perspectives

    Chapter 2024
    

11. Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial

    Background

    Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing...

    Nalinie Joharatnam-Hogan, Duaa Hatem, ... Ruth E. Langley in British Journal of Cancer

    Article Open access 07 July 2023
    

12. Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype

    The aim of this study was to investigate coenzyme Q10 (CoQ ₁₀ ) biosynthesis pathway defects in inherited retinal dystrophy. Individuals affected by...

    Neringa Jurkute, Francesca Cancellieri, ... Gavin Arno in npj Genomic Medicine

    Article Open access 20 October 2022
    

13. De Novo Sphingolipid Biosynthesis in Atherosclerosis

    Atherosclerosis is the formation of fibrofatty lesions in the arterial wall, and this inflammatory state of the artery is the main cause of advanced...

    Tae-Sik Park, Shivani Devi, ... Kyung-Hee Cho in Sphingolipid Metabolism and Metabolic Disease

    Chapter 2022
    

14. Three R2R3-MYB transcription factors from banana (Musa acuminata) activate structural anthocyanin biosynthesis genes as part of an MBW complex

    Objective

    Bananas are one of the most popular fruits in the world, providing food security and employment opportunities in several develo**...

    Mareike Busche, Boas Pucker, ... Ralf Stracke in BMC Research Notes

    Article Open access 13 June 2023
    

15. Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19

    The persistence of coronavirus disease 2019 (COVID-19)-related hospitalization severely threatens medical systems worldwide and has increased the...

    Fengjiao Liu, Huqin Yang, ... Jieqiong Li in Journal of Translational Medicine

    Article Open access 04 July 2024
    

16. The Effects of Modulators of the Coenzyme A Biosynthesis System on Metabolic Stress and the Glutathione System in the CNS in Aluminum Neurotoxicosis

    Abstract —Alzheimer’s-like disease was simulated in female adult Wistar CRL(WI) WUBR rats by 6-week intragastric administration of aluminum chloride...

    D. S. Semenovich, V. A. Gurinovich, ... A. G. Moiseenok in Neurochemical Journal

    Article 01 March 2023

17. Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics

    Kaempferia species have contained various crucial ethnobotanical features, and are being used as traditional folk medicines in some Southeast Asia....

    Chu Anh Van, Dau Xuan Duc, Ninh The Son in Medicinal Chemistry Research

    Article 21 November 2023
    

18. Expression of Carotenoid Biosynthesis Genes during the Long-Term Cold Storage of Potato Tubers

    Abstract

    Carotenoids are secondary metabolites that are synthesized and stored in all types of plant plastids. These pigments play a significant role...

    A. V. Kulakova, A. V. Shchennikova, E. Z. Kochieva in Russian Journal of Genetics

    Article 01 August 2023
    

19. Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer

    Background

    Genetic background plays an important role in the occurrence and development of gastric cancer (GC). With the application of genome-wide...

    Yuqi Chen, Wenying Yan, ... Weichang Chen in Journal of Experimental & Clinical Cancer Research

    Article Open access 30 January 2023
    

20. Metagenomic insights into the microbe-mediated B and K₂ vitamin biosynthesis in the gastrointestinal microbiome of ruminants

    Background

    B and K ₂ vitamins, essential nutrients in host metabolism, can be synthesized by the rumen microbiome in ruminants and subsequently...

    Qian Jiang, Limei Lin, ... Shengyong Mao in Microbiome

    Article Open access 21 July 2022