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Biogenesis and Functions of Extracellular Vesicles
Extracellular vesicles (EVs) contain various biomolecules, including proteins, nucleic acids, lipids, and metabolites. Multiple intracellular...
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microRNAs in action: biogenesis, function and regulation
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to...
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METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis
BackgroundPeriodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction....
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VEGFR2 blockade inhibits glioblastoma cell proliferation by enhancing mitochondrial biogenesis
BackgroundGlioblastoma is an aggressive brain tumor linked to significant angiogenesis and poor prognosis. Anti-angiogenic therapies with vascular...
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Mobile MicroRNAs: Potential for MicroRNA Biogenesis
As shown in Chap. 2 , the short interfering RNA (siRNA) system was thought to be the same as the microRNA (miRNA)...
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The Role of PGC-1α-Mediated Mitochondrial Biogenesis in Neurons
Neurons are highly dependent on mitochondrial ATP production and Ca 2+ buffering. Neurons have unique compartmentalized anatomy and energy...
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The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection
BackgroundThe blacklegged tick, Ixodes scapularis , transmits most vector-borne diseases in the US. It vectors seven pathogens of public health...
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Ribosome Biogenesis Methods and Protocols
This Open Access volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50...
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Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer
Exosomes are well-known key mediators of intercellular communication and contribute to various physiological and pathological processes. Their...
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Shikonin blocks CAF-induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3β/NEDD4-1 mediated phosphorylation-dependent degradation of PGC-1α
BackgroundTriple-negative breast cancer (TNBC) is characterized by its high metastatic potential, which results in poor patient survival....
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GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice
Mitochondrial dysfunction and excessive reactive oxygen species production due to impaired mitochondrial biogenesis have been proven to exacerbate...
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The nucleolus of Giardia and its ribosomal biogenesis
G iardia duodenalis is a protozoan intestinal parasite that causes a significant number of infections worldwide each year, particularly in low-income...
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Genomic analyses reveal the stepwise domestication and genetic mechanism of curd biogenesis in cauliflower
Cauliflower ( Brassica oleracea L. var. botrytis ) is a distinctive vegetable that supplies a nutrient-rich edible inflorescence meristem for the human...
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Anti-leukemia effects of omipalisib in acute myeloid leukemia: inhibition of PI3K/AKT/mTOR signaling and suppression of mitochondrial biogenesis
Omipalisib (GSK2126458), a potent dual PI3K/mTOR inhibitor, is reported to exhibit anti-tumor effect in several kinds of cancers. More than 50% of...
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Biogenesis of Mitochondria in Multipotent Mesenchymal Stromal Cells in Patients with Acute Leukemia
In patients with acute leukemia, not only normal hematopoiesis, but also bone marrow stromal microenvironment is damaged. Multipotent mesenchymal...
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Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1α Pathway in Male Rats
Heat shock protein 22 (hsp22) plays a significant role in mitochondrial biogenesis and redox balance. Moreover, it’s well accepted that the...
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ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/β-catenin pathway
BackgroundCircular RNAs (circRNAs) circularized by back-splicing of pre-mRNA are widely expressed and affected the proliferation, invasion and...
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Carbon Monoxide Stimulates Both Mitophagy And Mitochondrial Biogenesis to Mediate Protection Against Oxidative Stress in Astrocytes
Astrocytes are key glial cells for the metabolic and functional support of the brain. Mitochondrial quality control (MQC), in particular the balance...
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An inside out journey: biogenesis, ultrastructure and proteomic characterisation of the ectoparasitic flatworm Sparicotyle chrysophrii extracellular vesicles
BackgroundHelminth extracellular vesicles (EVs) are known to have a three-way communication function among parasitic helminths, their host and the...
