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Spatial architectures of somatic mutations in normal prostate, benign prostatic hyperplasia and coexisting prostate cancer
This study aimed to identify somatic mutations in nontumor cells (NSMs) in normal prostate and benign prostatic hyperplasia (BPH) and to determine...
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Kolaviron modulates angiogenesis, apoptosis and inflammatory signaling in rat model of testosterone propionate-induced benign prostate hyperplasia
Benign prostatic hyperplasia (BPH) is a non-malignant disease of the prostate characterized by uncontrolled proliferation of the prostate gland....
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Ablative minimally invasive surgical therapies for benign prostatic hyperplasia: A review of Aquablation, Rezum, and transperineal laser prostate ablation
IntroductionBenign prostatic hyperplasia (BPH) is one of the most common diseases affecting men and can present with bothersome lower urinary tract...
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Gut Microbiota Disorders in Obesity-Associated Benign Prostatic Hyperplasia in Rats
Benign prostatic hyperplasia (BPH), commonly seen in older men, can cause symptoms of discomfort, and may even need surgical intervention. Studies...
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Polygenic risk score predicting susceptibility and outcome of benign prostatic hyperplasia in the Han Chinese
BackgroundGiven the high prevalence of BPH among elderly men, pinpointing those at elevated risk can aid in early intervention and effective...
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Investigating trends in interest for benign prostatic hyperplasia surgery options using Google Trends
Understanding patient interest among surgical options is challenging. We used Google Trends to analyze interest in benign prostatic hyperplasia (BPH)...
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Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
BackgroundBenign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critical factor in its...
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Top-down holmium laser enucleation of the prostate (HoLEP) versus traditional HoLEP for the treatment of benign prostatic hyperplasia (BPH): 1-year outcomes of a randomized controlled trial
BackgroundThe top-down holmium laser enucleation of the prostate (HoLEP) technique recently emerged as a safe and effective modification of...
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Modeling of Benign Prostatic Hyperplasia in Rats with a High Dose of Testosterone
In order to optimize the testosterone model of benign prostatic hyperplasia, we studied the effect of castration and different doses of testosterone...
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Differential diagnosis of prostate cancer and benign prostatic hyperplasia based on DCE-MRI using bi-directional CLSTM deep learning and radiomics
Dynamic contrast-enhanced MRI (DCE-MRI) is routinely included in the prostate MRI protocol for a long time; its role has been questioned. It provides...
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Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate
ObjectiveBenign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in...
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Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
BackgroundThe pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an...
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Cyclooxygenase-2 activates EGFR–ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia
Objective and designProstatic inflammation is the driving force in benign prostatic hyperplasia (BPH). This work investigated the potential...
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Two-year long-term follow-up of treatment with the Optilume BPH catheter system in a randomized controlled trial for benign prostatic hyperplasia (The PINNACLE Study)
BackgroundPatient outcomes were assessed 2 years after treatment with the Optilume BPH Catheter System, a minimally invasive surgical therapy for the...
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Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia
ObjectiveProliferative nodular formation represents a characteristic pathological feature of benign prostatic hyperplasia (BPH) and serves as the...
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Efficacy and safety of dutasteride with tadalafil add-on therapy in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia
ObjectiveTo evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil in Japanese men with lower...
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Screening Methods for the Evaluation of Drugs for Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) affects majority of the older male population. Lower urinary tract symptoms are commonly seen in patients...
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Can ChatGPT provide high-quality patient information on male lower urinary tract symptoms suggestive of benign prostate enlargement?
BackgroundChatGPT has recently emerged as a novel resource for patients’ disease-specific inquiries. There is, however, limited evidence assessing...
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Pharmacotherapy vs. minimally invasive therapies as initial therapy for moderate-to-severe benign prostatic hyperplasia: a cost-effectiveness study
BackgroundRecently, minimally invasive therapies (MITs), such as water vapor thermal therapy (WVTT) and prostatic urethral lift (PUL) have become an...
