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Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway
BackgroundProstate cancer (PCa) is becoming the most common malignancy in men worldwide. We investigated the effect of astragaloside IV combined with...
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Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1
BackgroundAstragaloside IV (AS-IV) is one of the basic components of Astragali radix , that has been shown to have preventive effects against various...
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Blockade of PI3K/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier
BackgroundThe specific pathogenesis of UC is still unclear, but it has been clear that defects in intestinal barrier function play an important role...
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Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes–induced cognitive impairment
This study is to observe the upregulation effect of astragaloside IV on ghrelin in diabetic cognitive impairment (DCI) rats and to investigate the...
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Astragaloside IV Inhibits Rotenone-Induced α-syn Presentation and the CD4 T-Cell Immune Response
The increased α-synuclein (α-syn)-dependent activation of CD4 T cells leads to the progressive loss of dopaminergic (DA) neurons in the substantia...
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Nrf2 knockout attenuates the astragaloside IV therapeutic effect on kidney fibrosis from liver cancer by regulating pSmad3C/3L pathways
Fibrotic kidney injury from hepatocarcinogenesis seriously impacts treatment effect. Astragaloside IV (AS-IV), an extract of Astragalus membranaceus,...
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Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling
BackgroundAstragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV...
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Chitosan/Polylactic Acid Nanofibers Containing Astragaloside IV as a New Biodegradable Wound Dressing for Wound Healing
The ideal wound dressing should adequately protect the wound from bacterial infection and provide a suitable healing environment for the wound. Thus,...
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Astragaloside IV suppresses migration and invasion of TGF-β1-induced human hepatoma HuH-7 cells by regulating Nrf2/HO-1 and TGF-β1/Smad3 pathways
Astragaloside IV (AS-IV), one of the major compounds extract from Astragalus membranaceus, has shown attractive anti-cancer effects in certain...
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Protective effects of Astragaloside IV against oxidative injury and apoptosis in cultured astrocytes by regulating Nrf2/JNK signaling
Ischemic stroke is a worldwide complex brain disease that results in numerous disabilities and deaths. It leads to the deprivation of oxygen and...
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Astragaloside IV Exerts Anti-tumor Effect on Murine Colorectal Cancer by Re-educating Tumor-Associated Macrophage
Astragaloside IV (AS-IV) has shown anti-tumorigenic properties in certain cancers for its effect of boosting the body’s immune system, but its role...
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Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease
BackgroundSenescent astrocytes have been implicated in the aging brain and neurodegenerative disorders, including Parkinson’s disease (PD)....
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Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1
Astragaloside IV (ASV), which has several pharmacological abilities, shows potential therapeutic effects on certain cancers by regulating the...
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Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro
Amyotrophic lateral sclerosis (ALS), also known as a major type of motor neuron disease, is a disease characterized by the degeneration of both upper...
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Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress
BackgroundAstragalus membranaceus , a traditional Chinese medicine (TCM), has been widely used in the treatment of chronic kidney disease (CKD) in...
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Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice
The aim of this study was to investigate the effects of Astragaloside IV (AS) on cigarette smoke (CS)-induced chronic obstructive pulmonary disease...
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Herbal Approaches for the Management of Neurological Disorders
Neurological disorder like epilepsy, Alzheimer’s, and Parkinson’s disease is manifested by extensive morbidity, disability, along high rate of...
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Pharmacokinetics Comparison, Intestinal Absorption and Acute Toxicity Assessment of a Novel Water-Soluble Astragaloside IV Derivative (Astragalosidic Acid, LS-102)
Background and ObjectivesAstragaloside IV (AGS IV) is the most important bioactive constituent of Radix Astragali. However, its disappointing...
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Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Pulmonary fibrosis (PF) is the end stage of lung injury and chronic lung diseases that results in diminished lung function, respiratory failure, and...
