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FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to...
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MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules bind antigens that differ in...
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CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid...
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A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help....
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Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation
ObjectiveThis study aims to investigate the role of Acyl-CoA synthetase 4 (ACSL4) in mediating mitochondrial fatty acid metabolism and dendritic cell...
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Detection of Antigen Presentation by Murine Bone Marrow–Derived Dendritic Cells After Treatment with Nanoparticles
Nanoparticles are frequently considered in vaccine applications due to their ability to co-deliver multiple antigens and adjuvants to...
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Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells
As a potential vectored vaccine, Newcastle disease virus (NDV) has been subject to various studies for vaccine development, while relatively little...
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Integrating single-cell and bulk RNA sequencing data unveils antigen presentation and process-related CAFS and establishes a predictive signature in prostate cancer
BackgroundCancer-associated fibroblasts (CAFs) are heterogeneous and can influence the progression of prostate cancer in multiple ways; however,...
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Antigen
An antigen is a molecule which, when introduced parenterally into the body, initiates the production of an antibody with which it reacts specifically...
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Engineering Cell Lines for Specific Human Leukocyte Antigen Presentation
Epitope-specific immunotherapies have enabled the targeted treatment of a variety of diseases, ranging from cancer, infection, and autoimmune...
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Antigen-Presenting Cells and MHCs
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity
In breast cancer, genetic heterogeneity, the lack of actionable targets and immune evasion all contribute to the limited clinical response rates to...
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Lipid Metabolism and Tumor Antigen Presentation
Tumors always evade immune surveillance and block T cell activation in a poorly immunogenic and immunosuppressive environment. Cancer cells and...
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Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion
Immune checkpoint blockade, which blocks inhibitory signals of T cell activation, has shown tremendous success in treating cancer, although success...
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Multi-antigen spherical nucleic acid cancer vaccines
Cancer vaccines must activate multiple immune cell types to be effective against aggressive tumours. Here we report the impact of the structural...
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Cancer Antigens: Sources, Generation, and Presentation
Immune surveillance by T cells requires antigen presentation by molecules encoded by MHC (major histocompatibility complex) class I and class II...
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Protein-based antigen presentation platforms for nanoparticle vaccines
Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing...
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Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and...
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Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization...
