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Fortilin as a Biomarker in Toxicity
Fortilin, the multifunctional protein, also known as translationally controlled tumor protein (TCTP), presents in most eukaryotic organisms. It is...
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Natural Phenolic Compounds with Neuroprotective Effects
Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that...
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Fortilin as a Biomarker in Toxicity
Fortilin, the multifunctional protein, also known as translationally controlled tumor protein (TCTP), presents in most eukaryotic organisms. It is...
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SHARPIN: Role in Finding NEMO and in Amyloid-Beta Clearance and Degradation (ABCD) Pathway in Alzheimer’s Disease?
SHANK- associated RH domain-interacting protein (SHARPIN) is a multifunctional protein associated with numerous physiological functions and many...
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Mouse as a Preclinical Model for Studying Small Noncoding RNAs Involved in Colorectal Cancer
Colorectal cancer (CRC) is the third most diagnosed cancer and occupies the second position in death among other cancer deaths in both sexes due to...
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Role of ROS in Triggering Death Receptor-Mediated Apoptosis
Reactive oxygen species (ROS) are continuously produced and removed in live systems. In different concentrations, ROS has beneficial or harmful...
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Human mesenchymal stem cell secretomes: Factors affecting profiling and challenges in clinical application
The promising field of regenerative medicine is thrilling as it can repair and restore organs for various debilitating diseases. Mesenchymal stem...
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The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation,...
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Targeting WD repeat domain 5 enhances chemosensitivity and inhibits proliferation and programmed death-ligand 1 expression in bladder cancer
BackgroundChemotherapy and/or immunotherapy are first-line treatments for advanced muscle-invasive bladder cancer (BCa), but the unsatisfactory...
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Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis
Inflammation and apoptosis are common in many pathological conditions. Studies have shown that many natural compounds can regulate the signal...
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Targeting the MALAT1 gene with the CRISPR/Cas9 technique in prostate cancer
BackgroundThe MALAT1 lncRNA acts as an oncogene in Prostate cancer (PC); thus, it can be severe as a cancer biomarker.
MethodsUsing bioinformatics...
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When Glycosylation Meets Blood Cells: A Glance of the Aberrant Glycosylation in Hematological Malignancies
Among neoplasia-associated epigenetic alterations, changes in cellular glycosylation have recently received attention as a key component of...
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Mouse as a Preclinical Model for Studying Small Noncoding RNAs Involved in Colorectal Cancer
Colorectal cancer (CRC) is the third most diagnosed cancer and occupies the second position in death among other cancer deaths in both sexes due to...
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Low-dose metronomic cisplatin as an antiangiogenic and anti-inflammatory strategy for cancer
BackgroundConventional chemotherapy is based on the maximum tolerated dose (MTD) and requires treatment-free intervals to restore normal host cells....
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β-Catenin promotes long-term survival and angiogenesis of peripheral blood mesenchymal stem cells via the Oct4 signaling pathway
Stem cell therapy has been extensively studied to improve heart function following myocardial infarction; however, its therapeutic potency is limited...
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Current status and future prospects of stomatology research
Research in stomatology (dental medicine) continues to expand globally and is oriented towards solving clinical issues, focusing on clarifying the...
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Role of ROS in Triggering Death Receptor-Mediated Apoptosis
Reactive oxygen species (ROS) are continuously produced and removed in live systems. In different concentrations, ROS has beneficial or harmful...
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Combined effect of naringin and adipose tissue-derived mesenchymal stem cell on cisplatin nephrotoxicity through Sirtuin1/Nrf-2/HO-1 signaling pathway: a promising nephroprotective candidate
Cisplatin nephrotoxicity is a well-known emergency clinical condition caused by oxidative stress and inflammation. Naringin (NAR) is considered an...
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Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property
Grape seed proanthocyanidin extract (GSPE), an active component extracted from the grape, has been reported to demonstrate antioxidant,...
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Human amnion-derived mesenchymal stem cells improve subclinical hypothyroidism by immunocompetence mediating apoptosis inhibition on thyroid cells in aged mice
Subclinical hypothyroidism (SCH) affects 10% of the global population, which is most prevalent in women and the elderly. However, it remains...
