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The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
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Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
BackgroundAlternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently...
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Biological relevance of alternative splicing in hematologic malignancies
Alternative splicing (AS) is a strictly regulated process that generates multiple mRNA variants from a single gene, thus contributing to proteome...
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Gene expression and alternative splicing contribute to adaptive divergence of ecotypes
Regulation of gene expression is a critical link between genotype and phenotype explaining substantial heritable variation within species. However,...
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Alternative splicing in neurodegenerative disease and the promise of RNA therapies
Alternative splicing generates a myriad of RNA products and protein isoforms of different functions from a single gene. Dysregulated alternative...
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Alternative splicing and environmental adaptation in wild house mice
A major goal of evolutionary genetics is to understand the genetic and molecular mechanisms underlying adaptation. Previous work has established that...
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Genetic Mutations and Alternative Splicing in Schizophrenia
Genetic mutations are responsible for most neurogenetic disorders. Schizophrenia is a neurogenetic disorder; we focused on genetic mutations and...
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Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing
BackgroundImmunotherapies effectively treat human malignancies, but the low response and resistance are major obstacles. Neoantigen is an emerging...
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Insulin receptor alternative splicing in breast and prostate cancer
Cancer etiology represents an intricate, multifactorial orchestration where metabolically associated insulin-like growth factors (IGFs) and insulin...
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The implications of alternative pre-mRNA splicing in cell signal transduction
Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing,...
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SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis
BackgroundAberrant alternative splicing (AS) is a pervasive event during colorectal cancer (CRC) development. SF3B3 is a splicing factor component of...
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In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors
Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed...
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Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing
BackgroundDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets....
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Dysregulation of alternative splicing contributes to multiple myeloma pathogenesis
BackgroundDysregulation of alternative splicing (AS) triggers many tumours, understanding the roles of splicing events during tumorigenesis would...
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Regulation of Alternative Splicing of Lipid Metabolism Genes in Sepsis-Induced Liver Damage by RNA-Binding Proteins
RNA binding proteins (RBPs) have the potential for transcriptional regulation in sepsis-induced liver injury, but precise functions remain unclear....
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Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance
BackgroundDespite advances in therapeutic strategies, resistance to immunotherapy and the off-target effects of targeted therapy have significantly...
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Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms....
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Alternative splicing in multiple myeloma is associated with the non-homologous end joining pathway
Alternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern and pathogenic role has not been systematically...
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Virus usurps alternative splicing to clear the decks for infection
Since invasion, there will be a tug-of-war between host and virus to scramble cellular resources, for either restraining or facilitating infection....
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Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing
BackgroundCircular RNAs (circRNAs) contribute to multiple biological functions and are also involved in pathological conditions such as cancer....
