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Hospitalisations related to benzodiazepine, Z-drug, and opioid treatment in Italy: a claim on the risks associated with inappropriate use
PurposeBenzodiazepines (BZD), Z-drugs (ZD), and opioids share a high risk of abuse. This study assessed and characterised adverse events (AEs)...
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Factors associated with long-term benzodiazepine and Z-drug use across the lifespan and 5-year temporal trajectories among incident users: a Swedish nationwide register-based study
PurposeDespite being discouraged by guidelines, long-term use of benzodiazepines and related Z-drugs (BZDR) remains frequent in the real-world. An...
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Engineered lipid liquid crystalline nanoparticles as an inhaled nanoplatform for mucus penetration enhancement
Nanocarrier-assisted pulmonary drug delivery system has been widely employed for lung local disease treatment due to its enhanced drug lesion...
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Topical Cream Carrying Drug-Loaded Nanogels for Melanoma Treatment
In this study, nanogel creams carrying paclitaxel (PTX) and temozolomide (TMZ) were prepared for the topical treatment of melanoma. PTX and TMZ were...
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Identification, synthesis and quantification of eutylone consumption markers in a chemsex context
Eutylone is a cathinone-derived synthetic amphetamine scheduled by the World Health Organization and European Monitoring Centre for Drugs and Drug...
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Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review
PurposeInsomnia is highly prevalent in older persons and significantly impacts quality of life, functional abilities, and health status. It is...
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Diffuse subtype-specific gastric carcinogenesis associated with dysregulation of Notch signaling pathways
Gastric tumors are the third leading cause of cancer-related mortality worldwide. This study investigates the effects of Notch signaling pathway...
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Efficacy and safety of traditional Chinese medicine in the treatment of menopause-like syndrome for breast cancer survivors: a systematic review and meta-analysis
BackgroundIn recent years, breast cancer (BC) incidence and mortality have been the highest in females. Menopause-like syndrome (MLS), arising from...
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Effect of Verapamil, a P-glycoprotein-1 and Cytochrome P450 3A4 Inhibitor, on Pharmacokinetics and Metabolic Stability of Ripretinib: A Drug–Drug Interaction Study in Rats
Background and ObjectivesRipretinib was developed to target a whole range of KIT proto-oncogene mutations and platelet-derived growth factor receptor...
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Improving cognitive function with intermittent dose escalation of curcumin extract in chemotherapy-induced cognitive impairment patients: a randomized controlled trial
Chemotherapy-induced cognitive impairment (CICI) is an impairment of memory, learning power, concentration, reasoning, executive function, attention,...
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Determinants of Biological Half-Lives and Terminal Slopes in Physiologically Based Pharmacokinetic Systems: Assessment of Limiting Conditions
In pharmacokinetic (PK) analyses, the biological half-life T 1/2 is usually determined in the terminal phase after drug administration, which is...
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Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women
BackgroundThe use of cannabis has been clinically associated with decreased motivation to engage in normally rewarding activities. However, evidence...
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Spatial visualization of drug uptake and distribution in Fasciola hepatica using high-resolution AP-SMALDI mass spectrometry imaging
Understanding drug penetration, distribution, and metabolization is fundamental for understanding drug efficacy. This also accounts for parasites...
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Development of Delayed Release Oral Formulation Comprising Esomeprazole Spray Dried Dispersion Utilizing Design of Experiment As An Optimization Strategy
Solid dispersion (SD) technology is one of the most widely preferred solubility enhancement methods, especially for Biopharmaceutics classification...
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Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat
Bitopertin, a selective glycine transporter 1 (GlyT 1 ) inhibitor, has been extensively studied for the treatment of schizophrenia, with known safety...
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Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino
Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome ( Cnidii Rhizoma ; “ Senkyu ” in Japanese) and...
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Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity
BackgroundIndividual assessment of CYP enzyme activities can be challenging. Recently, the potato alkaloid solanidine was suggested as a biomarker...
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A Simple One-Parameter Percent Dissolved Versus Time Dissolution Equation that Accommodates Sink and Non-sink Conditions via Drug Solubility and Dissolution Volume
In vitro dissolution generally involves sink conditions, so dissolution equations generally do not need to accommodate non-sink conditions. Greater...
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Dissolution Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling
The present work aimed to differentiate between in vitro dissolution profiles of ibuprofen as input for GastroPlus™ and to see the impact on systemic...
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Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes
BackgroundType 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic...
