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PRMT4 drives post-ischemic angiogenesis via YB1/VEGF signaling
AbstractAngiogenesis is an integral process in many ischemic disorders, and vascular endothelial growth factor (VEGF) plays an important role in it....
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BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition
BackgroundBRD7 is a tumor suppressor known to inhibit cell proliferation and cell cycle progression and initiate apoptosis in breast cancer. However,...
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rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway
BackgroundActivation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein...
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The WAVE3/β-catenin oncogenic signaling regulates chemoresistance in triple negative breast cancer
BackgroundMetastatic breast cancer is responsible for the death of the majority of breast cancer patients. In fact, metastatic BC is the 2nd leading...
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Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines
PurposeFLT3 mutations occurred in approximately one third of patients with acute myeloid leukemia (AML). FLT3-ITD mutations caused the constitutive...
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Role of the long non-coding RNAs in regulation of Gemcitabine response in tumor cells
Chemotherapy is widely used as one of the first line therapeutic methods in cancer patients. However, chemotherapeutic resistance is one of the most...
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ROS Modulatory Role of HDAC Inhibitors in Cancer Cells
Histone deacetylase (HDAC) inhibitors represent a novel class of therapeutic agents for cancer treatment. These enzymes play a pivotal regulatory...
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ROS Modulatory Role of HDAC Inhibitors in Cancer Cells
Histone deacetylase (HDAC) inhibitors represent a novel class of therapeutic agents for cancer treatment. These enzymes play a pivotal regulatory...
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Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models
BackgroundTyrosine kinase inhibitors (TKIs) are mainstays of cancer treatment. However, their clinical benefits are often constrained by acquired...
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Ceritinib is a novel triple negative breast cancer therapeutic agent
BackgroundTriple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents...
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The role of the ZEB1–neuroinflammation axis in CNS disorders
Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells...
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LncRNA HCP5 Facilitates the Progression of Ovarian Cancer by Interacting with the PTBP1 Protein
Ovarian cancer (OC) is a major gynecological malignancy with an annually increasing morbidity that poses a significant threat to the health of women...
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Leave no stone unturned: individually adapted xerotolerant Thaumarchaeota sheltered below the boulders of the Atacama Desert hyperarid core
BackgroundThe hyperarid core of the Atacama Desert is an extremely harsh environment thought to be colonized by only a few heterotrophic bacterial...
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RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment
Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a...
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MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation
BackgroundAltered glycolysis is the most fundamental metabolic change associated with the Warburg effect. Some glycolytic enzymes such as PKM2, the...
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Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis
Nucleolin (NCL) is a multifunctional protein expressed in the nucleus, cytoplasm, and cell membrane. Overexpression of NCL has a controversial role...
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Y-Box-Binding Protein-1
Various reports have proved that Y-box-binding protein-1 (YB-1) is a protein with multiple roles including transcription/translation regulation of...
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Y-Box-Binding Protein-1
Various reports have proved that Y-box-binding protein-1 (YB-1) is a protein with multiple roles including transcription/translation regulation of...
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p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy
Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein...
