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Structural disconnection is associated with disability in the neuromyelitis optica spectrum disorder
ObjectivesNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system. Accumulating evidence...
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Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
The existence of lymphatic vessels or similar clearance systems in the central nervous system (CNS) that transport nutrients and remove cellular...
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Neuromyelitis optica: a pilot study of clinical presentation and status of serological biomarker AQP4 among patients admitted to a tertiary centre in NCNS, Sudan
BackgroundNeuromyelitis optica (NMO) is a demyelinating disease primarily affecting the optic nerves and spinal cord. It is distinguished from other...
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Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
MECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders...
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Proteomic profiles of major serum proteins in seropositive NMO patients alter after Rituximab treatment
Devic’s disease or neuromyelitis optica is an autoimmune inflammatory disease of the central nervous system that primarily affects the brain and...
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Acupuncture Treatment for Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, which affected millions of patients worldwide with no...
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Targeting Neuromyelitis Optica Pathogenesis: Results from Randomized Controlled Trials of Biologics
Advances in neuromyelitis optica spectrum disorder pathogenesis have allowed the development of targeted drugs. These treatments act on core elements...
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Is Fertility Affected in Women of Childbearing Age with Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder?
Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central nervous system (CNS), which is more prevalent among women...
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Anti-NMDAR Encephalitis with Relapsing Optic Neuritis
Autoimmune encephalitis with antibodies to NMDA receptors (anti-NMDAR encephalitis) is a frequent form of autoimmune encephalitis. The disease is...
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Epigenetics in Multiple Sclerosis
Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients slowly with physical, sensory and cognitive deficits. The...
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Fatigue
Fatigue is a subjective multidimensional illness that plays an immense role, sometimes having an even greater impact than symptoms such as pain,...
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Leber Hereditary Optic Neuropathy and Longitudinally Extensive Transverse Myelitis
Leber Hereditary Optic Neuropathy is an inherited optic neuropathy caused by mitochondrial DNA point mutations leading to sudden, painless loss of...
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First report of persistent dengue-1-associated autoimmune neurological disturbance: neuromyelitis optica spectrum disorder
Dengue virus (DENV) causes immune-mediated diseases. Neurological involvement represents a severe condition that is rarely observed in DENV-1...
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Association of TNFSF4 Polymorphisms with Neuromyelitis Optica Spectrum Disorders in a Chinese Population
The tumor necrosis factor ligand superfamily member 4 ( TNFSF4 ) gene encodes a vital co-stimulatory molecule of the immune system and has been...
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STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders
STAT4 plays a crucial role in the functioning of the innate and adaptive immune cells and has been identified as a susceptibility gene in numerous...
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Fatigue
Fatigue is a subjective multidimensional illness that plays an immense role, sometimes having an even greater impact than symptoms such as pain,...
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Immunomodulatory Therapy for Multiple Sclerosis
Substantial progress has been made over the past 25 years in terms of understanding the underlying pathophysiology, develo** diagnostic and...
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Combined brain and anterior visual pathways’ MRIs assist in early identification of neuromyelitis optica spectrum disorder at onset of optic neuritis
Acute optic neuritis (ON) is the initial presentation in half of neuromyelitis optica spectrum disorder (NMO-SD) cases. Our objective was to evaluate...
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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome
BackgroundMyelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are present in a subset of aquaporin-4 (AQP4)-IgG-negative patients with optic...
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Optic Nerve
Optic nerve diseases arise from many different etiologies including inflammatory, neoplastic, genetic, infectious, ischemic, and idiopathic....