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The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia
White matter injury is a progressive vascular disease that leads to neurological deficits and vascular dementia. It comprises up to 30% of all...
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Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia
BackgroundChronic cerebral ischemia induces white matter injury (WMI) contributing to cognitive decline. Both astrocytes and microglia play vital...
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Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models
Chronic cerebral hypoperfusion leads to white matter injury (WMI), which subsequently causes neurodegeneration and even cognitive impairment....
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Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep
BackgroundTherapeutic hypothermia significantly improves outcomes after moderate–severe hypoxic-ischemic encephalopathy (HIE), but it is partially...
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Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities
The major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the...
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White matter associations with spelling performance
Multiple neurocognitive processes are involved in the highly complex task of producing written words. Yet, little is known about the neural pathways...
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APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia
BackgroundWhite matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are...
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Experimental Ischemic Stroke Induces Secondary Bihemispheric White Matter Degeneration and Long-Term Cognitive Impairment
Clinical studies have identified widespread white matter degeneration in ischemic stroke patients. However, contemporary research in stroke has...
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Acupuncture Alleviates Chronic Ischemic White Matter Injury in SHR Rats via JNK-NMDAR Circuit
To study the protective mechanism of acupuncture at “Jiangya Recipe” on chronic ischemic white matter injury in spontaneously hypertensive rats (SHR)...
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Single-Cell Transcriptomics Revealed White Matter Repair Following Subarachnoid Hemorrhage
Existing research indicates the potential for white matter injury repair during the subacute phase following subarachnoid hemorrhage (SAH). However,...
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Brain white matter microstructural alterations in patients with systemic lupus erythematosus: an automated fiber quantification study
This study aimed to identify damaged segments of brain white matter fiber tracts in patients with systemic lupus erythematosus (SLE) using diffusion...
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Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities
BackgroundGrowing evidence suggests that not only cerebrovascular disease but also Alzheimer’s disease (AD) pathological process itself cause...
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Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells...
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CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis
BackgroundThis study aimed to investigate whether CXCL1/CXCR2 mediates intestinal injury or white matter injury by delivering inflammatory mediators...
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3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage
Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD)....
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CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway
BackgroundWhite matter injury (WMI) represents a significant etiological factor contributing to neurological impairment subsequent to Traumatic Brain...
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Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain
BackgroundIschemic stroke in white matter of the brain induces not only demyelination, but also neuroinflammation. Peripheral T lymphocytes,...
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Hormonal factors moderate the associations between vascular risk factors and white matter hyperintensities
To examine the moderation effects of hormonal factors on the associations between vascular risk factors and white matter hyperintensities in men and...
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A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis
Cerebral ischemic stroke causes substantial white matter injury, which is further aggravated by neuroinflammation mediated by microglia/astrocytes....
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Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion
Neuroinflammation is assumed as the critical pathophysiologic mechanism of white matter lesions (WMLs), and infiltrated peripheral monocyte-derived...
