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Identification of Novel Prognostic Long Non-coding RNAs in Lung Adenocarcinoma Using WGCNA Analysis
Long non-coding RNAs play crucial role in the tumorigenesis of lung adenocarcinoma (LUAD). However, the function of a large number of lncRNAs in LUAD...
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Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation
Osteoarthritis (OA) is a common chronic joint degenerative disease and a major cause of disability in the elderly. However, the current intervention...
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Identifying functional subtypes of IgA nephropathy based on three machine learning algorithms and WGCNA
BackgroundIgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, which is a significant cause of renal failure. At present, the...
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GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA
BackgroundStroke attributable to atrial fibrillation (AF related stroke, AFST) accounts for 13 ~ 26% of ischemic stroke. It has been found that AFST...
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Single-cell and WGCNA uncover a prognostic model and potential oncogenes in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Single-cell transcriptome sequencing (scRNA-seq)...
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Construction of CeRNA regulatory network based on WGCNA reveals diagnosis biomarkers for colorectal cancer
BackgroundColorectal cancer is the third most common cause of death among cancers in the world. Although improvements in various treatments have...
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FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA
BackgroundBeing the most common arrhythmia in clinic, atrial fibrillation (AF) causes various comorbidities to patients such as heart failure and...
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Construction of a ceRNA network of hub genes affecting immune infiltration in ovarian cancer identified by WGCNA
BackgroundOvarian cancer is the leading cause of death among gynecological malignancies. Immunotherapy has demonstrated potential effects in ovarian...
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A new finding in the key prognosis-related proto-oncogene FYN in hepatocellular carcinoma based on the WGCNA hub-gene screening trategy
BackgroundHepatocellular carcinoma (HCC) is the third-most deadly cancer worldwide. More breakthroughs are needed in the clinical practice for liver...
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Exploring the biological function of immune cell-related genes in human immunodeficiency virus (HIV)-1 infection based on weighted gene co-expression network analysis (WGCNA)
BackgroundAcquired immunodeficiency syndrome (AIDS) is a chronic infectious disease characterized by consistent immune dysfunction. The objective of...
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Identification of novel miRNAs potentially involved in the pathogenesis of adult T-cell leukemia/lymphoma using WGCNA followed by RT-qPCR test of hub genes
BackgroundAdult T-cell Lymphoma/Leukemia (ATLL) is characterized by the malignant proliferation of T-cells in Human T-Lymphotropic Virus Type 1 and a...
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Identification of key genes in hepatitis B associated hepatocellular carcinoma based on WGCNA
Chronic Infection of Hepatitis B virus (HBV) is one risk factor of hepatocellular carcinoma (HCC). Much effort has been made to research the process...
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Weighted Gene Co-expression Network Analysis and Machine Learning Validation for Identifying Major Genes Related to Sjogren’s Syndrome
Sjogren’s syndrome (SS) is an autoimmune disorder characterized by dry mouth and dry eyes. Its pathogenic mechanism is currently unclear. This study...
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Predictive Model to Identify the Long Time Survivor in Patients with Glioblastoma: A Cohort Study Integrating Machine Learning Algorithms
We aimed to develop and validate a predictive model for identifying long-term survivors (LTS) among glioblastoma (GB) patients, defined as those with...
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Identification of Key Genes and Immunological Features Associated with Copper Metabolism in Parkinson’s Disease by Bioinformatics Analysis
To explore diagnostic genes associated with cuproptosis in Parkinson’s disease (PD) and to characterize immune cell infiltration by comprehensive...
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ZAP70: A Key Gene Identified by Differential Expression Analysis for Early Diagnosis of Fetuses with Emanuel Syndrome
Emanuel syndrome is a rare autosomal disorder characterized by microcephaly, heart defects, cleft palate and developmental delay. However, there is a...
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Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
BackgroundPrenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of...
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SCUBE1 Promotes Gestational Diabetes Mellitus: A Bioinformatics and Experimental Investigation
Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women, posing significant risks to the life and health...
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Identification and Functional Investigation of Hub Genes Associated with Follicular Lymphoma
Follicular lymphoma (FL), the most common type of indolent lymphoma, originates from germinal center B cells within the lymphoid follicle. However,...
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Cancer-Associated Fibroblast-Related Genes Are Associated with Prognosis of Patients with Ovarian Cancer
AbstractThis study aimed to investigate the effects of cancer-associated fibroblasts (CAFs)-related genes on prognosis and immunity in ovarian...
