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Lower Limbs are the Most Difficult-to-Treat Body Region of Patients with Psoriasis: Pooled Analysis of CLEAR and CLARITY Studies of Secukinumab Versus Ustekinumab by Body Region
BackgroundThe impact of psoriasis, response to treatment, and patients’ perceptions of treatment satisfaction vary by body area.
Objectives ...
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Tirzepatide versus insulin glargine as second-line or third-line therapy in type 2 diabetes in the Asia-Pacific region: the SURPASS-AP-Combo trial
Tirzepatide is a once-weekly GIP/GLP-1 receptor agonist. In this phase 3, randomized, open-label trial, insulin-naive adults (≥18 years of age) with...
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Benign and Malignant Tumors of the Pineal Region
PinealPineal region tumors fall into five broad categories: benign pineal region tumorsBenign Pineal Region Tumors, glial tumors, papillaryPapillary...
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Vector Studies in the Amazon Basin Region of Peru
The isolation of Venezuelan equine encephalitis virus (VEEV) from Peruvian soldiers and our need for a field site to evaluate diagnostic assays being...
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Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial
INTRIGUE was an open-label, phase 3 study in adult patients with advanced gastrointestinal stromal tumor who had disease progression on or...
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Stereotactic ablative brachytherapy versus percutaneous microwave ablation as salvage treatments for lung oligometastasis from colorectal cancer
BackgroundThe treatment for lung oligometastasis from colorectal cancer (CRC) remains challenging. This retrospective study aimed to compare the...
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Recovery kinetics following sprint training: resisted versus unresisted sprints
PurposeTo determine the recovery kinetics of performance and exercise-induced muscle damage following different sprint-training protocols.
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Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer: long-term survival analysis of the DESTINY-Breast03 trial
Trastuzumab deruxtecan (T-DXd) demonstrated significantly improved efficacy over trastuzumab emtansine (T-DM1) in DESTINY-Breast03 (median follow-up,...
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Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study
Persistent inflammation is described in people with HIV (PWH) on antiretroviral treatment (ART). Early ART initiation is associated with reduced...
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Antimalarial artesunate–mefloquine versus praziquantel in African children with schistosomiasis: an open-label, randomized controlled trial
Schistosomiasis treatment entirely relies on a single drug, praziquantel, prompting research into alternative therapeutics. Here we evaluated the...
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Self-reported adherence to direct oral anticoagulants versus warfarin therapy in a specialized thrombosis service—a cross-sectional study of patients in a Canadian Health Region
PurposeDirect oral anticoagulants (DOACs) have a better safety and efficacy profile than warfarin and are currently recommended for stroke...
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Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
The generation of new myelin-forming oligodendrocytes in the adult central nervous system is critical for cognitive function and regeneration...
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Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer’s Disease
Both neurofibrillary tangles and senile plaques are associated with inflammation in Alzheimer’s disease (AD). Their relative degree of induced...
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Treatment-seeking behaviours of malaria patients versus non-malaria febrile patients along China-Myanmar border
BackgroundAppropriate malaria treatment-seeking behaviour (TSB) is critical for timely detecting malaria, prompt treatment, and prevention of onward...
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The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish
The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers graded forward locomotion. How MLR neurons recruit...
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Real-world overall survival with abiraterone acetate versus enzalutamide in chemotherapy-naïve patients with metastatic castration-resistant prostate cancer
BackgroundThere are no large head-to-head phase 3 clinical trials comparing overall survival (OS) for abiraterone and enzalutamide. This study used...
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Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease
Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. Recent literature has proposed two...
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Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial
The relationship between amyloidosis and vasculature in cognitive impairment and Alzheimer’s disease (AD) pathogenesis is increasingly acknowledged....
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Lower viral evolutionary pressure under stable versus fluctuating conditions in subzero Arctic brines
BackgroundClimate change threatens Earth’s ice-based ecosystems which currently offer archives and eco-evolutionary experiments in the extreme....
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Filarial Nematodes in Dogs from the Northeast Region of Brazil
PurposeMedical and veterinary filarial nematodes are transmitted by blood-feeding vectors. In dogs, these parasites are mainly represented by...
