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The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
BackgroundNF-κB signaling pathway participate closely in regulating inflammation and immune response in many cancers. Long non-coding RNAs (lncRNAs)...
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The value of case reports in rare oncological scenarios: mixed method analysis of colorectal metastases from breast cancer
With improved survival of cancer patients, we increasingly encounter infrequent metastatic locations. While for the common metastatic locations both...
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Linking Models with Brain Measures
Linking models and brain measures offers a number of advantages over standard analyses. Models that have been evaluated on previous datasets can...
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Comprehensive characterization of stemness-related lncRNAs in triple-negative breast cancer identified a novel prognostic signature related to treatment outcomes, immune landscape analysis and therapeutic guidance: a silico analysis with in vivo experiments
BackgroundCancer stem cells (CSCs) and long non-coding RNAs (lncRNAs) are known to play a crucial role in the growth, migration, recurrence, and drug...
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Association between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson’s disease (PD) utilizing prospective cohort...
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Low incidence of advanced neurological burden but high incidence of age-related conditions that are dementia risk factors in aging people living with HIV: a data-linkage 10-year follow-up study
Although increasing research is focusing on age-related comorbidities (ARC) among people living with HIV (PLHIV), no studies have concomitantly...
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Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity
BackgroundUnderstanding human genetic influences on the gut microbiota helps elucidate the mechanisms by which genetics may influence health...
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The causal associations of circulating lipids with Barrett’s Esophagus and Esophageal Cancer: a bi-directional, two sample mendelian randomization analysis
ObjectiveThe causal associations of circulating lipids with Barrett’s Esophagus (BE) and Esophageal Cancer (EC) has been a topic of debate. This...
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Elucidating the role of liver enzymes as markers and regulators in ovarian cancer: a synergistic approach using Mendelian randomization, single-cell analysis, and clinical evidence
ObjectiveTo investigate the association between liver enzymes and ovarian cancer (OC), and to validate their potential as biomarkers and their...
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Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model
BackgroundThe prognostic management of bladder cancer (BLCA) remains a great challenge for clinicians. Recently, bulk RNA-seq sequencing data have...
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Characterizing the Linkage of Systemic Hypoxia and Angiogenesis in High-Grade Glioma to Define the Changes in Tumor Microenvironment for Predicting Prognosis
High-grade gliomas (HGG) comprising WHO grades 3 and 4 have a poor overall survival (OS) that has not improved in the past decade. Herein, markers...
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Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants
Amylase activity and levels in humans are heritable quantitative traits. Although many studies exist on the effects of copy-number variants (CNVs) in...
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Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics
Genome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural...
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Integrated multi-omic analysis and experiment reveals the role of endoplasmic reticulum stress in lung adenocarcinoma
BackgroundLung cancer is a highly prevalent malignancy worldwide and is associated with high mortality rates. While the involvement of endoplasmic...
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Integrated analysis identifies GABRB3 as a biomarker in prostate cancer
BackgroundTreatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate...
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Clinical and genome-wide association analysis of chemoradiation-induced hearing loss in nasopharyngeal carcinoma
Chemoradiation-induced hearing loss (CRIHL) is one of the most devasting side effects for nasopharyngeal carcinoma (NPC) patients, which seriously...
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Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data
Background:Overall survival of advanced colorectal cancer (CRC) patients remains poor, and gene expression analysis could potentially complement...
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Influence of race and age in sleep duration and mortality relationship among adults in the United States: results from the 2004 NHIS-NDI record linkage study
Limited information exists on age and racial disparities in sleep duration and mortality in the United States (US) population. This study compared...
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Systematic Analysis of the Relationship Between Elevated Zinc and Epilepsy
Previous studies have indicated a potential relationship between zinc and epilepsy. The aim of this study is to investigate the causal relationship...
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An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma
BackgroundAccumulating evidence indicates that long non-coding RNAs (lncRNAs) are involving in the tumorigenesis and metastasis of lung cancer. The...
