Search
Search Results
-
Identification of UAP1L1 as a critical factor for prostate cancer and underlying molecular mechanism in tumorigenicity
BackgroundProstate cancer is the second most common cancer in men, and some new target genes are needed to predict the risk of prostate cancer...
-
Abnormal glycosylation in glioma: related changes in biology, biomarkers and targeted therapy
Glioma is a rapidly growing and aggressive primary malignant tumor of the central nervous system that can diffusely invade the brain tissue around,...
-
Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease
Kawasaki disease (KD) is a paediatric vasculitis associated with coronary artery aneurysms (CAA). Genetic variants influencing susceptibility to KD...
-
Identification of molecular signatures and pathways involved in Rett syndrome using a multi-omics approach
BackgroundRett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the methyl-CpG-binding protein 2 gene ( MECP2 ). MeCP2 is...
-
Cerebellar Long Noncoding RNA Expression Profile in a Niemann-Pick C Disease Mouse Model
Niemann-Pick type C (NP-C) disease is a neurodegenerative lysosomal storage disorder primarily caused by mutations in NPC1 . However, its pathogenesis...
-
Condition-specific gene co-expression network mining identifies key pathways and regulators in the brain tissue of Alzheimer’s disease patients
BackgroundGene co-expression network (GCN) mining is a systematic approach to efficiently identify novel disease pathways, predict novel gene...
-
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations
Heterozygous, loss-of-function mutations in the granulin gene ( GRN ) encoding progranulin (PGRN) are a common cause of frontotemporal dementia (FTD)....
-
Identification of TGFβ-induced proteins in non-endocrine mouse pituitary cell line TtT/GF by SILAC-assisted quantitative mass spectrometry
TtT/GF is a mouse cell line derived from a thyrotropic pituitary tumor and has been used as a model of folliculostellate cells. Our previous...
-
Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis
BackgroundGiant cell arteritis (GCA) is the most common form of vasculitis affecting elderly people. It is one of the few true ophthalmic emergencies...
-
Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain
BackgroundDissemination of breast cancers to the brain is associated with poor patient outcome and limited therapeutic options. In this study we...
-
Systematic analyses of glutamine and glutamate metabolisms across different cancer types
BackgroundGlutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of...
-
Differentially expressed protein-coding genes and long noncoding RNA in early-stage lung cancer
Due to the application of low-dose computed tomography screening, more and more early-stage lung cancers have been diagnosed. Thus, it is essential...
-
Integrated lipidomics and transcriptomic analysis of peripheral blood reveals significantly enriched pathways in type 2 diabetes mellitus
BackgroundInsulin resistance is a key element in the pathogenesis of type 2 diabetes mellitus. Plasma free fatty acids were assumed to mediate the...
-
Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis
Epigenetic gene regulation has influence over a diverse range of cellular functions, including the maintenance of pluripotency, differentiation, and...
