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Cell Models in Autophagy Research
Autophagy is highly conserved in organisms ranging from yeast to humans. C. elegans, D. melanogaster, zebrafish, and mice have been extensively used... -
A nanobody targeting the F-actin cap** protein CapG restrains breast cancer metastasis
IntroductionAberrant turnover of the actin cytoskeleton is intimately associated with cancer cell migration and invasion. Frequently however,...
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Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
Hypoxia presents pro-apoptotic and anti-apoptotic biphasic effects that appear to be dependent upon cell types and conditions around cells. The...
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AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
The transcription factor CCAAT/enhancer binding protein α, or C/EBPα, encoded by the CEBPA gene, is crucial for the differentiation of granulocytes....