Search
Search Results
-
Tumor Suppressor Genes
Tumor suppressors are the second major type of cancer genes. In contrast to oncogenes, tumor suppressor genes have to undergo loss of function to...
-
Tumor Suppressor Genes
The identification of recessive mutations that cause cancer solved the mystery of heritable cancer syndromes, and also provided a new perspective on...
-
Tumor Suppressor Genes and Cell Fate Control
In this chapter, we will present the transcription factor p53, which is encoded by the most prominent cancer driver gene, the tumor suppressor gene...
-
Metastasis suppressor genes and their role in the tumor microenvironment
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within...
-
Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma
BackgroundEpigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted...
-
Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma
BackgroundDeletion of 1p is associated with poor prognosis in neuroblastoma, however selected 1p-intact patients still experience poor outcomes....
-
Nontoxic Natural Products as Regulators of Tumor Suppressor Gene Function
Cancer is a multifactorial disorder caused by the accumulation of multiple genetic, epigenetic lesions or its combination on cancer critical genes,...
-
Tumor Suppressor Genes and Cell Fate Control
The transcription factor p53 is encoded by the most prominent cancer driver gene, the tumor suppressor gene TP53. Activated p53 proteins regulate...
-
A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity
BackgroundOsteosarcoma (OS) is one of most commonly diagnosed bone cancer. Circular RNAs (circRNAs) are a class of highly stable non-coding RNA, the...
-
Synaptopodin-2: a potential tumor suppressor
Initially identified as an actin-binding protein containing a PSD95-DLG-ZO1 Domain (PZD domain), Synaptopodin 2 (SYNPO2) has long been considered a...
-
Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response
BackgroundIdentification of driver mutations and development of targeted therapies has considerably improved outcomes for lung cancer patients....
-
Metastasis suppressor genes in clinical practice: are they druggable?
Since the identification of NM23 (now called NME1 ) as the first metastasis suppressor gene (MSG), a small number of other gene products and...
-
Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
BackgroundThe complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the...
-
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway
BackgroundHepatocellular carcinoma (HCC) has a high mortality rate, and the mechanisms underlying tumor development and progression remain unclear....
-
KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?
Present therapeutic approaches do not effectively target metastatic cancers, often limited by their inability to eliminate already-seeded...
-
DNA methylation analysis of tumor suppressor genes in liquid biopsy components of early stage NSCLC: a promising tool for early detection
PurposeCirculating tumor cells (CTCs) and circulating tumor DNA (ctDNA) analysis represents a liquid biopsy approach for real-time monitoring of...
-
Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs
BackgroundFibroblast growth factor receptor (FGFR) gene family alterations are found in several cancers, indicating their importance as potential...
-
Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation
The natural product Honokiol exhibits robust antitumor activity against a range of cancers, and it has also received approval to undergo phase I...
-
Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
Glioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans, exhibiting very bad...
-
Role of myeloid-derived suppressor cells in tumor recurrence
The establishment of primary tumor cells in distant organs, termed metastasis, is the principal cause of cancer mortality and is a crucial...
