Search
Search Results
-
Acute tryptophan depletion alters affective touch perception
RationaleAffiliative tactile interactions help regulate physiological arousal and confer resilience to acute and chronic stress. C-tactile afferents...
-
Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
BackgroundDysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining...
-
Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies
Backgroundl -Tryptophan ( l -Trp), an essential amino acid, is the only amino acid whose level is regulated specifically by immune signals. Most...
-
Immune regulation through tryptophan metabolism
Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected...
-
Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV
Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in...
-
High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism
BackgroundAberrant tryptophan (Trp)-kynurenine (Kyn) metabolism has been implicated in the pathogenesis of human disease. In particular, populations...
-
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
AbstractGut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain...
-
Serum indoleamine 2, 3-dioxygenase and tryptophan-2, 3-dioxygenase: potential biomarkers for the diagnosis of major depressive disorder
ObjectiveThe objective of this study was to observe the changes in the levels of indoleamine 2, 3-dioxygenase (IDO) and tryptophan-2, 3-dioxygenase...
-
Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2
BackgroundLactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus ...
-
Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy
ObjectiveThe purpose of this study was to describe the changes in the gut microbiome of patients with cirrhosis and hepatic encephalopathy (HE), as...
-
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice
BackgroundAdolescent depression is becoming one of the major public health concerns, because of its increased prevalence and risk of significant...
-
Conditional Protein Depletion in the Analysis of Antifungal Drug Resistance in Candida glabrata
This chapter illustrates a method to generate Candida glabrata conditional depletion mutants for SNF2, an ATPase subunit of the SWI/SNF chromatin...
-
Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine
This longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid...
-
Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach
RationaleDepression is a serious mood disorder, and crocetin has a variety of pharmacological activities, including antidepressant effect. The...
-
Metabolic Stress and Immunity: Nutrient-Sensing Kinases and Tryptophan Metabolism
The tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO-1) has gained major attention due the immunoregulatory nature of this pathway....
-
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that...
-
Metabolomics analysis reveals changes related to pseudocyst formation induced by iron depletion in Trichomonas vaginalis
BackgroundIron is an essential element for cellular functions, such as energy metabolism. Trichomonas vaginalis , a human urogenital tract pathogen,...
-
Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy
Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. A small subset of patients (<10%) with MG, have...
-
Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjögren’s syndrome
Myeloid-derived suppressor cells (MDSCs) comprise heterogeneous myeloid cell populations with immunosuppressive capacity that contribute to immune...
-
Facial expressions of pain: the role of the serotonergic system
RationaleAlthough interest in the neurobiology of facial communication of pain has increased over the last decades, little is known about which...
