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Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2
BackgroundLactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus ...
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Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study...
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Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies
Backgroundl -Tryptophan ( l -Trp), an essential amino acid, is the only amino acid whose level is regulated specifically by immune signals. Most...
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Light-Induced Histidine Adducts to an IgG1 Molecule Via Oxidized Histidine Residue and the Potential Impact of Polysorbate-20 Concentration
PurposeHistidine (His) undergoes light-induced reactions such as oxidation, crosslinking and addition. These reactions are initiated by singlet...
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Non-invasive Characterization of Glycosuria and Identification of Biomarkers in Diabetic Urine Using Fluorescence Spectroscopy and Machine Learning Algorithm
The current study presents a steadfast, simple, and efficient approach for the non-invasive determination of glycosuria of diabetes mellitus using...
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Introduction to Vomitus and Its Forensic Analysis
Vomiting is a gastrointestinal response to poisoning or drug overdose and also it can occur due to trauma faced in violent assault like in case of...
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Study of Modification of Drug Binding Site I of Human Serum Albumin by Sodium Hypochlorite by Time Resolved Fluorescent Spectroscopy
Abstract —The kinetics of fluorescence decay of the K-35 probe and the tryptophan amino acid residue were measured after the addition of sodium...
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IDO and TGF-β Inhibitors for the Treatment of Lung Cancer
Indoleamine-2,3-dioxygenase (IDO) is an enzyme that catalyzes the conversion of tryptophan to N-formylkynurenine, and it is the rate-limiting step in...
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Metabolic changes preceding bladder cancer occurrence among Korean men: a nested case-control study from the KCPS-II cohort
BackgroundBladder cancer (BLCA) research in Koreans is still lacking, especially in focusing on the prediction of BLCA. The current study aimed to...
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Unveiling the Detrimental Effect of Glipizide on Structure and Function of Catalase: Spectroscopic, Thermodynamics and Simulation Studies
Free radicals, products of oxidative processes, induce cellular damage linked to diseases like Parkinson's and diabetes due to increased reactive...
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GM2 Gangliosidosis: Whole-Exome Sequencing Reveals Novel Homozygous Pathogenic Variant within the HEXA Gene in Iranian Family
AbstractGM2 gangliosidosis is a hereditary lysosomal storage disorder resulting from mutations in the Hexosaminidase A (HEXA) gene, which leads to a...
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Metabolomics reveals the potential metabolic mechanism of infliximab against DSS-induced acute and chronic ulcerative colitis
Inflammatory bowel disease (IBD) is often accompanied by metabolic imbalance, and infliximab (IFX) can alleviate IBD symptoms, but its metabolic...
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Molecular Interaction of Functionalized Nanoplastics with Human Hemoglobin
Humans are exposed to excessive nanoplastics (NPs) which have ample affinity for globular proteins. We investigated the interaction of functionalized...
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Biological Evaluation and Binding Mechanism of 5-HT7 Specific Arylpiperazinyl–Alkyl Benzothiazolone: Radiobiology and Photo-physical Studies
Diversely substituted methoxy derivatives of arylpiperazinyl–alkyl benzothiazolone has been evaluated as specific probe for 5HT 7 . To determine the...
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Techniques for Develo** Reliable Machine Learning Classifiers Applied to Understanding and Predicting Protein:Protein Interaction Hot Spots
With machine learning now transforming the sciences, successful prediction of biological structure or activity is mainly limited by the extent and...
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The Redox State of Serum Albumin as a Potential Protein Nutrition Biomarker
Albumin comprises the largest part of total serum proteins in humans and is exclusively synthesized in the liver, before being distributed into the...
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The Redox State of Serum Albumin as a Potential Protein Nutrition Biomarker
Albumin comprises the largest part of total serum proteins in humans and is exclusively synthesized in the liver, before being distributed into the...
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Inhibitory Potential of Carnosine and Aminoguanidine Towards Glycation and Fibrillation of Albumin: In-vitro and Simulation Studies
Carnosine is beta-alanyl histidine, a dipeptide, endogenously produced in our body by the carnosine synthase enzyme. It is an antioxidant, thus...
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Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope
HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses...
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Association of TPH1 and TPH2 Gene Polymorphisms with the Risk of Develo** Psychoneurological Disorders
The question of the involvement of impairments to the metabolism of melatonin and its precursors (tryptophan and serotonin) in the development of...