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Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients
BackgroundMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic condition associated with post-infectious onset,...
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Promoter methylation of transient receptor potential melastatin-related 7 (TRPM7) predicts a better prognosis in patients with Luminal A breast cancers
Breast cancer is the most common female tumors arising worldwide, and genetic and epigenetic events are constantly accumulated in breast...
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Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target
Canonical or classical transient receptor potential (TRPC) proteins are nonselective cationic channels and a subset of TRP superfamily which are...
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Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated...
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The Effects of Carvacrol on Transient Receptor Potential (TRP) Channels in an Animal Model of Parkinson’s Disease
In this study, we aimed to investigate the effects of carvacrol (CA), a widely used phytochemical having anti-oxidant and neuroprotective effects, on...
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Transient Receptor Potential Channels: Multiple Modulators of Peripheral Neuropathic Pain in Several Rodent Models
Neuropathic pain, a prevalent chronic condition in clinical settings, has attracted widespread societal attention. This condition is characterized by...
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Uncovering the role of transient receptor potential channels in pterygium: a machine learning approach
ObjectivesWe aimed at identifying the role of transient receptor potential (TRP) channels in pterygium.
MethodsBased on microarray data GSE83627 and...
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Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients
The transient receptor potential melastatin 4 (TRPM4) is a Ca 2+ -activated nonselective monovalent cation channel belonging to the TRP channel...
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Research focus and thematic trends of transient receptor potential vanilloid member 1 research: a bibliometric analysis of the global publications (1990–2023)
Recently, various studies have been devoted to the study of transient receptor potential vanilloid member 1 (TRPV1)-related diseases, potential...
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Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of...
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Ion Channel Dysregulation Following Intracerebral Hemorrhage
Injury to the brain after intracerebral hemorrhage (ICH) results from numerous complex cellular mechanisms. At present, effective therapy for ICH is...
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Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients
BackgroundMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell...
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Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with a broad overlap of symptomatology with Post-COVID Syndrome...
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Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis
Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition...
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Characteristics of A-type voltage-gated K+ currents expressed on sour-sensing type III taste receptor cells in mice
Sour taste is detected by type III taste receptor cells that generate membrane depolarization with action potentials in response to HCl applied to...
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TRPC Channels in Cardiac Arrhythmia: Their Role during Purinergic Activation Induced by Ischemia
Cardiac electrical activity is mainly determined by a set of voltage-dependent channels that control depolarizing currents carried by Na+ and Ca2+...
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A biophysically comprehensive model of urothelial afferent neurons: implications for sensory signalling in urinary bladder
The urothelium is the innermost layer of the bladder wall; it plays a pivotal role in bladder sensory transduction by responding to chemical and...
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Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients
BackgroundChronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system...
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Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages
Chikungunya virus (CHIKV), a virus that induces pathogenic inflammatory host immune responses, is re-emerging worldwide, and there are currently no...
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NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+ mobilizing second messenger known to date. Major steps elucidating...