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Renin Angiotensin System in the Maturation and Failure of Arterio-Venous Fistula
An arteriovenous fistulaArteriovenous fistula (AVF) is the most used vascular access for hemodialysis but is associated with failure occurring within...
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Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are...
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Multi-omics analysis revealed TEK and AXIN2 are potential biomarkers in multifocal papillary thyroid cancer
BackgroundPapillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study...
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Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function
AimsLong-COVID occurs after SARS-CoV-2 infection and results in diverse, prolonged symptoms. The present study aimed to unveil potential mechanisms,...
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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2...
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Metabolic dependency of non-small cell lung cancer cells affected by three-dimensional scaffold and its stiffness
Three-dimensional (3D) extracellular matrix (ECM) microenvironment is an important regulator of the stiffness of the tumors. Cancer cells require...
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Heterozygous THBS2 pathogenic variant causes Ehlers–Danlos syndrome with prominent vascular features in humans and mice
Ehlers–Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate...
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The immune‐related biomarker TEK inhibits the development of clear cell renal cell carcinoma (ccRCC) by regulating AKT phosphorylation
BackgroundHigh immunogenicity is an important feature of ccRCC, but its underlying immune-related molecular mechanisms remain unclear. This study...
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In Vivo Targeting of the Neurovascular Unit: Challenges and Advancements
The blood–brain barrier (BBB) is essential for the homeostasis of the central nervous system (CNS). Functions of the BBB are performed by the...
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Inflammation and vascular remodeling in COVID-19 hearts
A wide range of cardiac symptoms have been observed in COVID-19 patients, often significantly influencing the clinical outcome. While the...
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Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease
BackgroundIdentifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify...
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Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
BackgroundFibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor...
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Promoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer
BackgroundIn tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly...
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Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis
BackgroundPathological neovascularization plays a pivotal role in the onset and progression of tumors and neovascular eye diseases. Despite notable...
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Tumor-Associated Macrophages: Reasons to Be Cheerful, Reasons to Be Fearful
Tumor microenvironment (TME) is a complex and constantly evolving entity that consists not only of cancer cells, but also of resident host cells and...
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N-Methyl-D-aspartate receptor activation, novel mechanism of homocysteine-induced blood–retinal barrier dysfunction
AbstractElevated levels of amino acid homocysteine (Hcy) recognized as hyperhomocysteinemia (HHcy) was reported in several human visual disorders,...
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Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation
BackgroundTumor angiogenesis is regarded as a rational anti-cancer target. The efficacy and indications of anti-angiogenic therapies in clinical...
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Upregulated Tie2 expression in plasma: a potential non-invasive biomarker for the diagnosis of breast cancer
Breast cancer is by far the most common malignancy found in women and causes a significant public health problem around the world. Early diagnosis of...
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Multi-omics reveal mechanisms of high enteral starch diet mediated colonic dysbiosis via microbiome-host interactions in young ruminant
BackgroundAlthough rumen development is crucial, hindgut undertakes a significant role in young ruminants’ physiological development. High-starch...
