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Administering a Behavioral Test Battery in Rodents
Although animal models cannot broadly represent uniquely human psychiatric or psychological syndromes such as anxiety, depression, or schizophrenia,...
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Assessing Depression and Cognitive Impairment Following Stroke and Neurotrauma: Behavioral Methods for Quantifying Impairment and Functional Recovery
Rodent models of stroke and neural injury are reliable and useful tools for testing new interventions and therapeutics. In addition to physical...
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3D Finite Element Model of Human Ear with 3-Chamber Spiral Cochlea for Blast Wave Transmission from the Ear Canal to Cochlea
Blast-induced auditory trauma is a common injury in military service members and veterans that leads to hearing loss. While the inner ear response to...
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Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex
BackgroundTuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum...
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Preclinical Models of THC and Nicotine Exposure During Adolescent Brain Development: Modeling Neuropsychiatric Phenotypes Related to Dopaminergic Transmission
Adolescence is a gradual transition period between childhood and adulthood, characterized by greater sensitivity to rewarding stimuli. Consistently,...
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Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and β subunits. The GlyR subunits play major roles in the...
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Influence of Cerebral Glucose Metabolism by Chronic Pain–Mediated Cognitive Impairment in Adolescent Rats
Chronic pain during adolescence can lead to mental health disorders in adulthood, but the underlying mechanism is still unclear. Furthermore, the...
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A Behavioral Test Battery to Assess Larval and Adult Zebrafish After Developmental Neurotoxic Exposure
Behavioral test batteries are valuable methods which allow outcomes with varying characteristics and neurobiological bases to be assessed and...
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Assessment of Sexual Reward with the Conditioned Place Preference Paradigm
Sexual behavior, as other naturally motivated behaviors such as eating behavior, involves mesolimbic circuits that belong to the reward system as...
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GR/P300 Regulates MKP1 Signaling Pathway and Mediates Depression-like Behavior in Prenatally Stressed Offspring
Accumulating evidence suggests that prenatal stress (PNS) increases offspring susceptibility to depression, but the underlying mechanisms remain...
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Paternal deprivation induces vigilance-avoidant behavior and accompanies sex-specific alterations in stress reactivity and central proinflammatory cytokine response in California mice (Peromyscus californicus)
RationaleEarly-life stress (ELS) can increase anxiety, reduce prosocial behaviors, and impair brain regions that facilitate emotional and social...
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Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
Rationale/ObjectivesTargeting cannabinoid receptor type 1 (CB1R) has shown promise for treating opioid withdrawal symptoms. This study aimed to...
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Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex
Sociability stands as a crucial factor in the evolutionary success of all mammalian species. Notably, enriched environment (EE) housing has been...
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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence
BackgroundClinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead...
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Integrin β3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice
BackgroundAutism spectrum disorder (ASD) is characterized by repetitive behaviors, deficits in communication, and overall impaired social...
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Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis
Autism is a neurodevelopmental condition, and it's associated pathophysiology, viz., oxidative stress and altered cellular homeostasis, has been...
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Exploring Astrocytes Involvement and Glutamate Induced Neuroinflammation in Chlorpyrifos-Induced Paradigm Of Autism Spectrum Disorders (ASD)
Autism spectrum disorders (ASD) are neurodevelopmental disorders manifested mainly in children, with symptoms ranging from social/communication...
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Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task
BackgroundAttentional deficits are among the most common pain-induced cognitive disorders. Pain disrupts attention and may excessively occupy...
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Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles
BackgroundDepression is a disorder twice as common in women than in men. There are sex differences in the symptomatology and treatment response to...
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Basic Protocols to Study Parental Behavior in Rats
Maternal care is an affiliative, motivated, and complex social behavior that has been conserved through evolution to ensure the survival of the...