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The relationship between balance control and thigh muscle strength and muscle activity in persons with incomplete spinal cord injury
Study designCross-sectional study.
ObjectivesA spinal cord injury (SCI) can compromise the ability to maintain sufficient balance control during...
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Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers
BackgroundEMLA cream is a local anesthetic. The pharmacokinetics and dermal effects of a topical anesthetic formulation has not been evaluated in...
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Diagnostic value of skin RT-QuIC in Parkinson’s disease: a two-laboratory study
Skin α-synuclein deposition is considered a potential biomarker for Parkinson’s disease (PD). Real-time quaking-induced conversion (RT-QuIC) is a...
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How to activate the glutes best? Peak muscle activity of acceleration-specific pre-activation and traditional strength training exercises
PurposeIsometric training and pre-activation are proven to enhance acceleration performance. However, traditional strength training exercises do not...
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A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I
Leukocyte adhesion deficiency is an autosomal recessive primary immunodeficiency that has been divided into three types: LAD1 (beta-2 integrin (CD18)...
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Preclinical validation and treatment of volumetric modulated arc therapy based total bone marrow irradiation in Halcyon™ ring gantry linear accelerator
AimThis study aims to report preclinical validation, and the first clinical treatment of total bone marrow irradiation (TMI) and total bone marrow...
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Predictive factors, preventive implications, and personalized surgical strategies for bone metastasis from lung cancer: population-based approach with a comprehensive cancer center-based study
BackgroundBone metastasis (BM) and skeletal-related events (SREs) happen to advanced lung cancer (LC) patients without warning. LC-BM patients are...
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Measures of Neuromuscular Function
Measures of neuromuscular function are commonly obtained in the research disciplines of aging, disease physiology, and exercise science. The methods...
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The Role of Upper Body Motions in Stationary Ball-Kicking Motion: A Systematic Review
A ball-kicking motion requires a coordinated sequencing of all body segments for maximum ball release speed. Evidence of the role of upper body...
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel kappa opioid receptor agonist ZYKR1: a randomized double-blind placebo-control phase 1 study in healthy adult human participants
To perform first-in-human single-dose escalation trial of ZYKR1, which is a potent, selective, and peripherally-restricted kappa opioid receptor...
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Formation and Analysis of Biofilms in Vivo
Establishing a biofilm infection model in vivo allows a better understanding of the underlying infection mechanisms of bacteria. Here we describe a...
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Intramedullary endodermal cyst including glial tissues in the spinal cord
IntroductionSpinal intramedullary endodermal cyst is a rare spinal cord tumour. In particular, an endodermal cyst that includes glial tissues is...
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Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Neuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating magnetic fields (2 kHz and...
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Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG
Osteoarthritis is a bone and joint condition characterized pathologically by articular cartilage degenerative damage and can develop into a...
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Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles
The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also in many cases of post-infectious syndromes,...
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Feasibility study of volumetric modulated arc therapy with Halcyon™ linac for total body irradiation
BackgroundThe use of total body irradiation (TBI) with linac-based volumetric modulated arc therapy (VMAT) has been steadily increasing. Helical...
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Usefulness of fat-containing agents: an initial study on estimating fat content for magnetic resonance imaging
This initial study aimed at testing whether fat-containing agents can be used for the fat mass estimation methods using magnetic resonance imaging...
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A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS
Energy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while...
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Automated, IMU-based spine angle estimation and IMU location identification for telerehabilitation
BackgroundTelerehabilitation is a promising avenue for improving patient outcomes and expanding accessibility. However, there is currently no...
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Advanced harmonization techniques result in accurate establishment of in vitro–in vivo correlations for oxybenzone from four complex dermal formulations with reapplication
Due to high variability during clinical pharmacokinetic (PK) evaluation, the prediction of in vivo exposure from in vitro absorption testing of...
