Search

Search Results

1. Potential therapeutic effects of crocin

   Crocin, a natural bioactive compound derived from saffron ( Crocus sativus ) and other Crocus genera, has gained significant attention recently due to...

   Laleh Pourmousavi, Rasoul Hashemkandi Asadi, ... Roghayeh Pouzesh Jadidi in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 17 May 2024
   

2. New Antifungal Drugs: Discovery and Therapeutic Potential

   There has been an increase in invasive fungal infections, which are a universal problem due to the longer average lifespan, the number of...

   Francisca Vicente, Fernando Reyes, Olga Genilloud in Fungi Bioactive Metabolites

   Chapter 2024
   

3. The Presynaptic α2δ Protein Family and Their Therapeutic Potential

   α2δ proteins are well-established modulators of membrane expression and biophysical properties of voltage-gated calcium channels. Moreover, they are...

   Cornelia Ablinger, Clarissa Eibl, ... Gerald J. Obermair in Ion Channels as Targets in Drug Discovery

   Chapter 2024
   

4. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer’s

   Alzheimer is characterized by the gradual loss of memory, thinking, brain functions, and behavioral alterations that ultimately interfere with the...

   Tabassum Zafar, Ab Qayoom Naik, Bashirulla Shaik in Deciphering Drug Targets for Alzheimer’s Disease

   Chapter 2023
   

5. CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

   CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8...

   Choong-Hyun Koh, Suyoung Lee, ... Yeonseok Chung in Experimental & Molecular Medicine

   Article Open access 01 November 2023
   

6. CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

   Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and...

   **ao-Ling Chen, Quan-Dan Tan, ... Jie Yang in Neurochemical Research

   Article 08 December 2023
   

7. Protease-Activated Receptors (PARs): Biology and Therapeutic Potential in Perioperative Stroke

   Perioperative stroke is a devastating complication that occurs during surgery or within 30 days following the surgical procedure. Its prevalence...

   Theodoros Mavridis, Theodora Choratta, ... Athanasios Chalkias in Translational Stroke Research

   Article 07 February 2024
   

8. Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target

   Canonical or classical transient receptor potential (TRPC) proteins are nonselective cationic channels and a subset of TRP superfamily which are...

   Hussein N. Rubaiy in Ion Channels as Targets in Drug Discovery

   Chapter 2024
   

9. Necroptosis inhibitors: mechanisms of action and therapeutic potential

   Necroptosis is a type of programmed cell death that is morphologically similar to necrosis. This type of cell death is involved in various...

   Yingbo Zhou, Zhangtao Cai, ... Zhenyu Cai in Apoptosis

   Article 24 November 2023
   

10. GLP and G9a histone methyltransferases as potential therapeutic targets for lymphoid neoplasms

    Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering...

    Amandda Évelin Silva-Carvalho, Luma Dayane Carvalho Filiú-Braga, ... Felipe Saldanha-Araujo in Cancer Cell International

    Article Open access 12 July 2024
    

11. Extracellular Vesicles in Cardiovascular Pathophysiology: Communications, Biomarkers, and Therapeutic Potential

    Extracellular vesicles (EVs) are diverse, membrane-bound vesicles released from cells into the extracellular environment. They originate from either...

    Zhe Cui, Ling Zhang, ... Fuyang Zhang in Cardiovascular Toxicology

    Article 07 June 2024
    

12. Therapeutic potential of antimicrobial peptides against pathogenic protozoa

    Protozoal infections cause significant morbidity and mortality in humans and animals. The use of several antiprotozoal drugs is associated with...

    Corina Lobato Hagemann, Alexandre José Macedo, Tiana Tasca in Parasitology Research

    Article 05 February 2024
    

13. Neuroprotective Therapeutic Potential of microRNA-149-5p against Murine Ischemic Stroke

    Ischemic stroke resulting from blockade of brain vessels lacks effective treatments, prompting exploration for potential therapies. Among promising...

    Samira Vahidi, Mohammad-Reza Bigdeli, ... Mehrdad Roghani in Molecular Neurobiology

    Article 04 April 2024
    

14. Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein

    Intracellular retrograde transport in eukaryotic cells relies exclusively on the molecular motor cytoplasmic dynein 1. Unlike its counterpart,...

    **-Gyeong Park, Hanul Jeon, ... In-Gyun Lee in Experimental & Molecular Medicine

    Article Open access 01 April 2024
    

15. Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825

    Background

    Myeloid differentiation factor-88 (MyD88) is a crucial adapter protein that coordinates the innate immune response and establishes an...

    Meiqi Liu, Wenyan Kang, ... Yang Zhang in Inflammation Research

    Article 09 October 2023
    

16. Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review

    Background

    Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by...

    Tomoaki Aoki, Yusuke Endo, ... Kei Hayashida in Journal of Translational Medicine

    Article Open access 03 March 2024
    

17. Therapeutic Potential of Nanocrystals for Targeting Lymphoid Carcinoma

    Globally, cancer ranks second for mortality rate with the mark of >ten million deaths in 2020 only. Cancer is characterized by the transmutation of...

    Akshada S. Mhaske, Rahul Shukla in Handbook of Oncobiology: From Basic to Clinical Sciences

    Reference work entry 2024
    

18. Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis

    Biologics have become increasingly prominent as therapeutics in recent years due to their innate immune-privileged nature, biocompatibility, and high...

    Jithu Jerin James, K. V. Sandhya, ... S. Bharath in AAPS PharmSciTech

    Article 18 June 2024
    

19. The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases

    Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded...

    Arazu Sharif, John Mamo, ... Ryu Takechi in Translational Neurodegeneration

    Article Open access 22 January 2024
    

20. Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

    We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug...

    Yijun Cheng, Yuting Dai, ... Zhe Bao Wu in Acta Neuropathologica Communications

    Article Open access 18 April 2024