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Engineering Selective TIMPs Using a Counter-Selective Screening Strategy
The yeast surface display platform provides a powerful approach for screening protein diversity libraries to identify binders with an enhanced...
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Disturbed Matrix Metalloproteinases Activity in Age-Related Macular Degeneration
Matrix metalloproteinases (MMPs) are a tightly regulated family of proteolytic enzymes that break down extracellular matrix (ECM) and basement...
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Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) can be characterised in vivo by biomarkers reflecting amyloid-β (Aβ) and tau pathology. However, there is a need...
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Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
BackgroundTo evaluate the potential of cerebrospinal fluid (CSF) levels of matrix metalloproteinases and tissue-type inhibitors (MMP; TIMP), and...
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TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation
ObjectiveThe blood–brain barrier (BBB) plays a critical role in central nervous system homeostasis, and the integrity of BBB is disrupted in many...
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Zymography and Reverse Zymography for Testing Proteases and Their Inhibitors
Zymography is a powerful technique for the assay of different hydrolases that act upon any biological macromolecule. In particular, zymography is...
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The Role of Tissue Inhibitor of Metalloproteinase-1 and 2 in Echinococcus granulosus senso lato-Induced Human Hepatic Fibrosis
IntroductionThe main mechanism underlying hepatic fibrosis is the imbalance between tissue Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of...
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Fibrosis and bone marrow: understanding causation and pathobiology
Bone marrow fibrosis represents an important structural change in the marrow that interferes with some of its normal functions. The aetiopathogenesis...
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RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway
BackgroundPulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease with unknown etiology, associated with increasing morbidity and...
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Zymographic Techniques
Zymography is a broadly used method to study extracellular matrix-degrading enzymes, such as matrix metalloproteinases (MMPs), and antioxidative...
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Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice
Arterial hypertension (AH) leads to oxidative and inflammatory imbalance that contribute to fibrosis development in many target organs. Here, we...
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High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages
BackgroundEpidemiological studies have demonstrated that individuals with preexisting conditions, including diabetes mellitus (DM), are more...
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Deoxysphingolipids Upregulate MMP-1, Downregulate TIMP-1, and Induce Cytotoxicity in Human Schwann Cells
Sphingolipids are a heterogeneous class of lipids and essential components of the plasma membrane and plasma lipoproteins. Studies have shown that...
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Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials
Background/objectiveSystemic inflammation and oxidative stress (OS) are associated with breast cancer. CoQ10 as an adjuvant treatment with...
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Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease
Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently...
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The Link Between Matrix Metalloproteinases and Alzheimer’s Disease Pathophysiology
Alzheimer’s disease (AD) is a major contributor to dementia and the most common neurodegenerative disorder. In AD pathophysiology, matrix...
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Zymographic Techniques
Zymography is a broadly used method to study extracellular matrix-degrading enzymes, such as matrix metalloproteinases (MMPs), and antioxidative...
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Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway
Hypertensive cerebrovascular remodeling involves the enlargement of vascular smooth muscle cells (VSMCs), which activates volume-regulated Cl − ...
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Invasion und Metastasierung
Dieses Kapitel beschreibt Prozesse, Moleküle und Wechselwirkungen, die zur Invasion und Metastasierung beitragen, die am stärksten definierenden...
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Exercise training reduces systemic inflammation and improves general health status in female migraineurs: a randomised controlled trail
ObjectivesThe objectives of this study were to assess the effect of 8 weeks of moderate-intensity aerobic training on permeability inflammatory...
