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Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines
BackgroundClear cell sarcomas (CCSs) are translocated aggressive malignancies, most commonly affecting young adults with a high incidence of...
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Application of Laser Speckle Contrast Imaging (LSCI) for the Angiogenesis Measurement of Tumors in the Chorioallantoic Membrane (CAM) Model
Tumor angiogenesis is one essential aspect for the growth and metastasis of cancer cells, which means that adequate in vivo angiogenesis models are...
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Pseudotyped Viruses for the Alphavirus Chikungunya Virus
Members of the genus Alphavirus are mostly mosquito-borne pathogens that cause disease in their vertebrate hosts. Chikungunya virus (CHIKV), which is...
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Construction of a replication-competent retroviral vector for expression of the VSV-G envelope glycoprotein for cancer gene therapy
Gibbon ape leukemia virus (GALV) can infect a wide variety of cells but fails to infect most cells derived from laboratory mice. Transduction of...
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Pseudotyped Viruses for Mammarenavirus
Mammarenaviruses are classified into New World arenaviruses (NW) and Old World arenaviruses (OW). The OW arenaviruses include the first discovered...
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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
BackgroundSAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted...
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RET-independent signaling by GDNF ligands and GFRα receptors
The discovery in the late 1990s of the partnership between the RET receptor tyrosine kinase and the GFRα family of GPI-anchored co-receptors as...
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Osthole: an overview of its sources, biological activities, and modification development
Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens . It can be...
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Inhibition of the Voltage-Dependent K+ Current by the Tricyclic Antidepressant Desipramine in Rabbit Coronary Arterial Smooth Muscle Cells
We describe the effect of a tricyclic antidepressant drug desipramine on voltage-dependent K + (Kv) currents in freshly isolated rabbit coronary...
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Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
BackgroundThe identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for...
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Sialylation of N-glycans: mechanism, cellular compartmentalization and function
Sialylated N-glycans play essential roles in the immune system, pathogen recognition and cancer. This review approaches the sialylation of N-glycans...
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Recent Advances with ER Targeted Intrabodies
ER intrabodies are recombinant antibody fragments produced and retained in the endoplasmatic reticulum (ER) of a cell or an organism with the purpose...
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Assays for the Expression and Release of Insulin and Glucose-Regulating Peptide Hormones from Pancreatic β-Cell
The in vitro perfusion of the isolated rat pancreas as described by Anderson and Long (1947), Ross (1972), Grodsky and coworkers (1983, 1984), and...
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Humanin Derivatives Inhibit Necrotic Cell Death in Neurons
Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer’s disease. Herein, we identify a novel...
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[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats
Alzheimer disease (AD), a progressive neurodegenerative disorder, is characterized by cognitive decline and the accumulation of senile plaques in the...
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Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes
BackgroundSLC10A4 belongs to the solute carrier family SLC10 whose founding members are the Na + /taurocholate co-transporting polypeptide (NTCP, SLC10A1...
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Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim
BackgroundObatoclax is a clinical stage drug candidate that has been proposed to target and inhibit prosurvival members of the Bcl-2 family, and...
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Positive Inotropic Activity (Cardiac Glycosides)
Biological standardization of cardiac glycosides was necessary as long as the drugs used in therapy were plant extracts or mixtures of various...
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Expression of the immune regulation antigen CD70 in osteosarcoma
Osteosarcoma is the most frequent bone cancer in children and young adults. The outcome of patients with advanced disease is dismal. Exploitation of...
