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Protein–Protein Interaction via Two-Hybrid Assay in Yeast
The yeast two-hybrid assay enables detecting interactions between proteins, which makes this tool of particular interest for plant–virus interaction...
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Basal Transcriptional Machinery
In this chapter, we will discuss the impact of TSS regions, which are also known as core promoters. This is a prerequisite for understanding how...
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MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer
BackgroundThe long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) is a cancer biomarker. Furthermore, fusion of the MALAT1...
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Structure and function of the parvoviral NS1 protein: a review
Parvoviruses possess a single-stranded DNA genome of about 5 kb, which contains two open reading frames (ORFs), one encoding nonstructural (NS)...
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Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders
BackgroundHemoglobin is a tetramer consisting of two α-chains and two β-chains of globin. Hereditary aberrations in the synthesis of one of the...
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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing...
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Glutathionylation on RNA-binding proteins: a regulator of liquid‒liquid phase separation in the pathogenesis of amyotrophic lateral sclerosis
RNA-binding proteins (RBPs) containing low-sequence complexity domains mediate the formation of cellular condensates and membrane-less organelles...
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Candidate SNP Markers of Atherosclerosis That May Significantly Change the Affinity of the TATA-Binding Protein for the Human Gene Promoters
AbstractAtherosclerosis (AS) and AS-related pathologies such as coronary heart disease, myocardial infarction, angina pectoris, and stroke are the...
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An in vitro characterisation of the Trichomonas vaginalis TATA box-binding proteins (TBPs)
The protozoan parasite Trichomonas vaginalis is a common human pathogen from one of the earliest-diverging eukaryotic lineages. At the...
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SNP Analysis of TLR4 Promoter and Its Transcriptional Factor Binding Profile in Relevance to Bovine Subclinical Mastitis
Bovine mastitis is a complex infectious disease that develops in the mammary gland, predominantly caused by a bacterial infection of mammary tissue....
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MYC protein interactors in gene transcription and cancer
The transcription factor and oncoprotein MYC is a potent driver of many human cancers and can regulate numerous biological activities that contribute...
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Reduced oxidative stress suppresses neurotoxicity in the Drosophila model of TAF15-associated proteinopathies
TATA-binding protein associated factor 15 (TAF15) is involved in the pathology of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia...
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Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review
Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a...
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Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein
SNHG4 is a lncRNA that was previously reported to promote colorectal cancer (CRC) progression via molecular sponge mechanism. Bioinformatic analysis...
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The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain
BackgroundTristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding...
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Crosstalk between endoplasmic reticulum and cytosolic unfolded protein response in tomato
Conditions that cause proteotoxicity like high temperature trigger the activation of unfolded protein response (UPR). The cytosolic (CPR) and...
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Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression
The liver is known to possess remarkable regenerative potential, but persistent inflammation or severe acute injury can lead to liver fibrosis and...
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CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells
Background: Circular RNAs (circRNAs) are covalently closed single-stranded RNAs with multiple biological functions. CircRNA.0007127 is derived from...
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Cold-inducible RNA-binding protein Cirp, but not Rbm3, may regulate transcript processing and protection in tissues of the hibernating ground squirrel
RNA-binding proteins (RBPs) have important roles in transcription, pre-mRNA processing/transport, mRNA degradation, translation, and non-coding RNA...
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Protein Condensation in the Nuclear Receptor Family; Implications for Transcriptional Output
The nuclear receptorNuclear receptors superfamily is a group of transcriptional regulators that orchestrate multiple vital processes such as...