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1. Prognostic impact of severe neutropenia in colorectal cancer patients treated with TAS-102 and bevacizumab, addressing immortal-time bias

   Background

   Several studies have reported an association between severe neutropenia and long-term survival in patients treated with...

   Daichi Watanabe, Hironori Fujii, ... Nobuhisa Matsuhashi in BMC Cancer

   Article Open access 08 November 2023
   

2. Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment

   Background

   TAS-102 (Lonsurf ^® ) is an oral fluoropyrimidine consisting of a combination of trifluridine (a thymidine analog) and tipiracil (a thymidine...

   Alessandro Ottaiano, Mariachiara Santorsola, ... Michele Caraglia in Journal of Translational Medicine

   Article Open access 22 April 2024
   

3. Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with ⁹⁰Y resin microspheres for chemo-refractory colorectal liver metastases

   Background

   Extrahepatic disease progression limits clinical efficacy of Yttrium-90 ( ⁹⁰ Y) radioembolization (TARE) for patients with...

   Nicholas Fidelman, Chloe E. Atreya, ... Katherine Van Loon in BMC Cancer

   Article Open access 13 December 2022
   

4. Retrospective cohort study of trifluridine/tipiracil (TAS-102) plus bevacizumab versus trifluridine/tipiracil monotherapy for metastatic colorectal cancer

   Background

   A previous phase I/II C-TASK FORCE study of trifluridine/tipiracil plus bevacizumab for patients with heavily pretreated metastatic...

   Daisuke Kotani, Yasutoshi Kuboki, ... Takayuki Yoshino in BMC Cancer

   Article Open access 27 December 2019
   

5. Chemotherapy re-use versus anti-angiogenic monotherapy as the third-line treatment of patients with metastatic colorectal cancer: a real-world cohort study

   Background

   There are various recommendations for third-line treatment in mCRC, however, there is no consensus on who is more suitable for particular...

   **g**g Duan, Lila Zhu, ... Ting Deng in BMC Cancer

   Article Open access 05 March 2024
   

6. A synthetic control arm for refractory metastatic colorectal cancer: the no placebo initiative

   Takayuki Yoshino, Qian Shi, ... Aimery de Gramont in Nature Medicine

   Article 28 July 2023
   

7. Alexithymia, impulsiveness, emotion, and eating dyscontrol: similarities and differences between narcolepsy type 1 and type 2

   Non-sleep symptoms, as depression, anxiety and overweight, are often encountered in narcoleptic patients. The purposes of this study are to evaluate...

   Chiara Del Bianco, Martina Ulivi, ... Francesca Izzi in Sleep and Biological Rhythms

   Article Open access 05 September 2022

8. Precision medicine applied to metastatic colorectal cancer using tumor-derived organoids and in-vitro sensitivity testing: a phase 2, single-center, open-label, and non-comparative study

   Background

   Patients with colorectal metastatic disease have a poor prognosis, limited therapeutic options, and frequent development of resistance....

   Lars Henrik Jensen, Silvia Regina Rogatto, ... Torben Frøstrup Hansen in Journal of Experimental & Clinical Cancer Research

   Article Open access 05 May 2023
   

9. Evaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorder

   Abstract

   Some findings have emerged from the field of oxidative stress in patients with psychiatric disorders. These date also state that oxidative...

   Eser Sağaltıcı, Hasan Belli, ... Hasan Gökçay in Neurochemical Journal

   Article 01 March 2024

10. Oxidative Stress and Migraine

    The pathogenesis of migraine is not completely understood, but inflammation and oxidative stress seem to be involved, according to data from an...

    Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, ... José A. G. Agúndez in Molecular Neurobiology

    Article 18 March 2024
    

11. Integrated transmission assessment surveys (iTAS) of lymphatic filariasis and onchocerciasis in Cross River, Taraba and Yobe States, Nigeria

    Background

    Integrated transmission assessment surveys (iTAS) have been recommended for evaluation of the transmission of both lymphatic filariasis...

    Ifeoma N. Anagbogu, Yisa A. Saka, ... Zaiyanatu Abubakar Umar in Parasites & Vectors

    Article Open access 13 June 2022
    

12. Trifluridine–tipiracil plus bevacizumab versus trifluridine–tipiracil monotherapy for chemorefractory metastatic colorectal cancer: a systematic review and meta-analysis

    Colorectal cancer is the leading cause of cancer death worldwide. The first and second lines of treatment for metastatic colorectal cancer (mCRC)...

    Francisco Cezar Aquino de Moraes, Felipe Dircêu Dantas Leite Pessôa, ... Ney Pereira Carneiro dos Santos in BMC Cancer

    Article Open access 03 June 2024
    

13. Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy

    The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor...

    ** Chen, Zhijie Xu, ... Yuanliang Yan in Biomarker Research

    Article Open access 07 January 2024
    

14. p73 isoforms meet evolution of metastasis

    Cancer largely adheres to Darwinian selection. Evolutionary forces are prominent during metastasis, the final and incurable disease stage, where...

    Stella Logotheti, Athanasia Pavlopoulou, ... Thorsten Stiewe in Cancer and Metastasis Reviews

    Article 11 August 2022
    

15. Comparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal cancer

    Background

    The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been the...

    Elif Şenocak Taşçı, Başak Oyan, ... Mustafa Bozkurt in BMC Cancer

    Article Open access 02 January 2024
    

16. Registry-derived stage (RD-Stage) for capturing cancer stage at diagnosis for endometrial cancer

    Background

    Capture of cancer stage at diagnosis is important yet poorly reported by health services to population-based cancer registries. In this...

    S. M. Evans, K. Ivanova, ... K. Williams in BMC Cancer

    Article Open access 12 December 2023

17. Eco-friendly Fluorescent Sensor for Sensitive and Selective Detection of Zn²⁺ and Fe³⁺ Ions: Applications in Human Hair Samples

    A new eco-friendly sensor, 3-((6-((4-chlorobenzylidene)amino)pyridin-2-yl)imino)indolin-2-one ( CBAPI ) was synthesized and well characterized. The CBAPI ...

    Rasha M. Kamel, Sahar S. El-Sakka, ... M. H. A. Soliman in Journal of Fluorescence

    Article Open access 03 July 2024
    

18. Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments

    Colorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes one of the most important...

    Roya Abedizadeh, Fateme Majidi, ... Davood Sabour in Cancer and Metastasis Reviews

    Article 19 December 2023
    

19. Expanding the Biocatalysis Toolbox

    Research directed toward the development of biocatalytic platforms has been sparked by successful applications of enzymes for sustainable...

    Rajesh Kumar, Carlos A. Martinez, John W. Wong in Green Chemistry in Drug Discovery

    Protocol 2022
    

20. Endpoints for Pharmacotherapy Trials for Alcohol Use Disorder

    Alcohol use disorder (AUD) is a debilitating disorder, yet currently approved pharmacotherapies to treat AUD are under-utilized. The three...

    Malia A. Belnap, Kaitlin R. McManus, ... Lara A. Ray in Pharmaceutical Medicine

    Article Open access 05 July 2024