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A T follicular helper cell origin for T regulatory type 1 cells
Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4 + T cells into T regulatory type 1 (TR1) cells, a subset of...
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Detection of T Follicular Helper Cells and T Follicular Regulatory Cells in Experimental Sjögren’s Syndrome
With the compiling studies on the autoimmune pathogenesis in the develo** of Sjögren’s syndrome, the functional importance of T follicular helper...
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The Use of Peptide-MHCII Tetramers to Identify Antigen-Specific T Follicular Helper and T Follicular Regulatory Cells
Characterization and counting of the different immune cell subpopulations are largely used in order to predict the quality of vaccination or the...
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Analysis of the In Vivo Function of Follicular Regulatory T (TFR) Cells in the Regulation of Antibody Response
Follicular regulatory T (TFR) cells, a subset of Foxp3+ regulatory T cells (Tregs), play an essential role in the regulation of germinal center (GC)...
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Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development
The immunological mechanisms underlying chronic colitis are poorly understood. T follicular helper (T FH ) cells are critical in hel** B cells during...
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Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging
The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A...
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The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BackgroundHIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within...
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Identification of Follicular T Cells in the Gut
Humoral adaptive immune responses trigger the establishment of plasma B cells secreting antibodies of various isotypes that bind antigen specifically...
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Regulatory T Cells for Control of Autoimmunity
Regulatory T (Treg) cells, which specifically express the master transcription factor FoxP3, are indispensable for the maintenance of immunological...
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Identification of Human Blood and Tissue T Follicular Regulatory (Tfr) Cells by Flow Cytometry
T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells are crucially involved in the regulation of germinal center reactions. Thus,...
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Identification of Human T Follicular Cells in Ectopic Lymphoid Structures
T follicular helper (Tfh) and T follicular regulatory (Tfr) cells are the two T cell subsets able to interact with B cells driving germinal center...
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The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3 + regulatory T (T reg ) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper...
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Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy
Immune-checkpoint blockade (ICB) has shown remarkable clinical success in boosting antitumor immunity. However, the breadth of its cellular targets...
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The link between circulating follicular helper T cells and autoimmunity
Follicular helper T (T FH ) cells provide help to B cells, supporting the formation of germinal centres that allow affinity maturation of antibody...
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Regulatory T cells in the face of the intestinal microbiota
Regulatory T cells (T reg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders....
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IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
The inability of neonates to develop CD4 + FoxP3 - CXCR5 hi PD-1 hi T follicular helper (T FH ) cells contributes to their weak vaccine responses. In previous...
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Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases
T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody...
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Induced regulatory T cells remain suppressive capability on effector T cells and synovial fibroblasts in collagen-induced arthritis
Rheumatoid arthritis (RA) is a common autoimmune disorder initiated by inflammatory synovitis. Hyperproliferation of destructive synovial fibroblasts...
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CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients...
