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Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription
Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships between TFs,...
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Natural agents as wound-healing promoters
AbstractThe management of acute and chronic wounds resulting from diverse injuries poses a significant challenge to clinical practices and healthcare...
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Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy
Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and solid cancers. Despite the transformative impact of...
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MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density
BackgroundInherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is...
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Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters
Recombinant adeno-associated viral vectors (AAVs) are an effective system for gene transfer. AAV serotype 2 (AAV2) is commonly used to deliver...
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The Application Potential of Synthetic Biology in Microbial Communication
Purpose of ReviewQuorum sensing (QS) signals are very important in microbial communication. In recent years, some new technologies, such as synthetic...
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Undergraduate Students’ Engineering Systems Thinking in Synthetic Biology Design: A Qualitative Descriptive Study
The design of biological systems is a multidisciplinary activity in which biomedical engineers collaborate to build novel biological systems that...
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Engineering living therapeutics with synthetic biology
The steadfast advance of the synthetic biology field has enabled scientists to use genetically engineered cells, instead of small molecules or...
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Optimal design of synthetic circular RNAs
Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently linked via back-splicing. Due to their versatility, the need to...
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Transcription factor competition at the γ-globin promoters controls hemoglobin switching
BCL11A, the major regulator of fetal hemoglobin (HbF, α 2 γ 2 ) level, represses γ-globin expression through direct promoter binding in adult erythroid...
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Synthetic biomarkers: a twenty-first century path to early cancer detection
Detection of cancer at an early stage when it is still localized improves patient response to medical interventions for most cancer types. The...
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DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers
Enhancer sequences control gene expression and comprise binding sites (motifs) for different transcription factors (TFs). Despite extensive genetic...
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Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy
Cancer immunotherapies rely on one or few specific tumour-associated antigens. However, the adaptive immune system relies on a large and diverse...
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Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy
BackgroundWe reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively...
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A new era of stem cell and developmental biology: from blastoids to synthetic embryos and beyond
Recent discoveries in stem cell and developmental biology have introduced a new era marked by the generation of in vitro models that recapitulate...
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Using Models to (Re-)Design Synthetic Circuits
Mathematical models play an important role in the design of synthetic gene circuits, by guiding the choice of biological components and their...
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DNA origami: a tool to evaluate and harness transcription factors
Alongside other players, such as CpG methylation and the “histone code,” transcription factors (TFs) represent a key feature of gene regulation. TFs...
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A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota
BackgroundSuccessful chemoprevention or chemotherapy is achieved through targeted delivery of prophylactic agents during initial phases of...
