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Complex synthetic lethality in cancer
The concept of synthetic lethality has been widely applied to identify therapeutic targets in cancer, with varying degrees of success. The standard...
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Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in GC targeted therapies has...
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Synthetic Lethality and Lung Cancer
Synthetic lethality happens between two genes that the mutation of either gene is feasible but the mutation of both concurrently leads to viability...
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Synthetic lethality in personalized cancer therapy
Genomic instability is one of the hallmarks of tumors that contributes to tumor heterogeneity and drug resistance. Genetically targeted cancer...
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Exploring the DNA damage response pathway for synthetic lethality
Synthetic lethality (SL) describes a situation in which the occurrence of one genetic event maintains cell viability, whereas the co-occurrence of...
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ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors
PurposePARP inhibitors (PARPi) are effective in homologous recombination repair (HRR) defective (HRD) cancers. To (re)sensitise HRR proficient (HRP)...
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Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency
BackgroundTargetable molecular drivers of gastric cancer (GC) metastasis remain largely unidentified, leading to limited targeted therapy options for...
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PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes
BackgroundSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have...
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Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific...
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A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells
Current concepts in treating cancer usually neglect individual tumor characteristics such as a given mutational make up. Consequently, a...
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Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality
BackgroundSynthetic lethality describes a genetic interaction between two perturbations, leading to cell death, whereas neither event alone has a...
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Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer
BackgroundOncogenic KRAS mutations are prevalent in human cancers, but effective treatment of KRAS -mutant malignancies remains a major challenge in...
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A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy
BackgroundAdvances in cancer biology are increasingly dependent on integration of heterogeneous datasets. Large-scale efforts have systematically...
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Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers
Mutant isocitrate dehydrogenase 1/2 (mIDH1/2) gain a novel function for the conversion of α -ketoglutarate ( α -KG) to oncometabolite...
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Leflunomide triggers synthetic lethality in PTEN-deficient prostate cancer
BackgroundThe loss of PTEN function presents in up to 50% of late-stage prostate cancers, and is therefore a potential target for therapeutics....
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Aurora kinase A, a synthetic lethal target for precision cancer medicine
Recent advances in high-throughput sequencing technologies and data science have facilitated the development of precision medicine to treat cancer...
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Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy
Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and solid cancers. Despite the transformative impact of...
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Epigenetic synthetic lethality approaches in cancer therapy
The onset and development of malignant tumors are closely related to epigenetic modifications, and this has become a research hotspot. In recent...
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Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers
BackgroundSomatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Here, we focused on...
