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Survival outcome of different treatment sequences in patients with locally advanced and metastatic pancreatic cancer
BackgroundDespite some therapeutic advances, improvement in survival rates of unresectable and/or metastatic pancreatic ductal adenocarcinoma (PDAC)...
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Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis
BackgroundThe aim of study was to evaluate survival outcome and limb function in cancer patients with proximal limbs metastasis. Associated factors...
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Integration of single-cell sequencing and bulk expression data reveals chemokine signaling pathway in proliferating cells is associated with the survival outcome of osteosarcoma
BackgroundOsteosarcoma, as the most common primary bone malignancy, is urgent to be well-studied on the biomarkers and therapeutic targets to improve...
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Flufenamic acid improves survival and neurologic outcome after successful cardiopulmonary resuscitation in mice
BackgroundBrain injury is the main cause of high mortality and disability after successful cardiopulmonary resuscitation (CPR) from sudden cardiac...
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COVPRIG robustly predicts the overall survival of IDH wild-type glioblastoma and highlights METTL1+ neural-progenitor-like tumor cell in driving unfavorable outcome
BackgroundAccurately predicting the outcome of isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) remains hitherto challenging. This study...
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IDH1 mutation is detectable in plasma cell-free DNA and is associated with survival outcome in glioma patients
BackgroundCirculating cell-free DNA (cfDNA, liquid biopsy) is a powerful tool to detect molecular alterations. However, depending on tumor...
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Non-invasive intravoxel incoherent motion MRI in prediction of histopathological response to neoadjuvant chemotherapy and survival outcome in osteosarcoma at the time of diagnosis
BackgroundEarly prediction of response to neoadjuvant chemotherapy (NACT) is important to aid personalized treatment in osteosarcoma....
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Overall survival of patients with hepatocellular carcinoma treated with sintilimab and disease outcome after treatment discontinuation
BackgroundThe use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research has been conducted...
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HER2 amplification level by in situ hybridization predicts survival outcome in advanced HER2-positive breast cancer treated with pertuzumab, trastuzumab, and docetaxel regardless of HER2 IHC results
BackgroundThe role of HER2 amplification level in predicting the effectiveness of HER2-directed therapies has been established. However, its...
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Association of pre-treatment lymphocyte-monocyte ratio with survival outcome in patients with head and neck cancer treated with chemoradiation
BackgroundGiven the role of systematic inflammation in cancer progression, lymphocyte-monocyte ratio (LMR) from peripheral blood has been suggested...
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Surrogacy of one-year survival for overall survival in advanced hepatocellular carcinoma
BackgroundThe increasing number of sequential treatments complicates the evaluation of overall survival (OS) in clinical trials for hepatocellular...
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Standardised survival probabilities: a useful and informative tool for reporting regression models for survival data
BackgroundWhen interested in studying the effect of a treatment (or other exposure) on a time-to-event outcome, the most popular approach is to...
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Cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer predict poor clinical outcome
BackgroundCancer-associated fibroblasts (CAFs) are a dominant cell type in the stroma of non-small cell lung cancer (NSCLC). Fibroblast heterogeneity...
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A population-based study of transformed marginal zone lymphoma: identifying outcome-related characteristics
Histological transformation of marginal zone lymphoma (tMZL) into diffuse large B-cell lymphoma is associated with poor outcomes. Clinical...
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Socio-economic and ethnic disparities in childhood cancer survival, Yorkshire, UK
BackgroundEstablishing the existence of health inequalities remains a high research and policy agenda item in the United Kingdom. We describe ethnic...
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A novel Iowa–Mayo validated composite risk assessment tool for allogeneic stem cell transplantation survival outcome prediction
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for many hematologic conditions and is associated with considerable...
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A joint international consensus statement for measuring quality of survival for patients with childhood cancer
The aim of treating childhood cancer remains to cure all. As survival rates improve, long-term health outcomes increasingly define quality of care....
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Analysis of cell free DNA to predict outcome to bevacizumab therapy in colorectal cancer patients
To predict outcome to combination bevacizumab (BVZ) therapy, we employed cell-free DNA (cfDNA) to determine chromosomal instability (CIN), nucleosome...
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Microbiological risk factors, ICU survival, and 1-year survival in hematological patients with pneumonia requiring invasive mechanical ventilation
PurposeTo identify pathogenic microorganisms and microbiological risk factors causing high morbidity and mortality in immunocompromised patients...
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Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
BackgroundMost gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has...
