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Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
BackgroundPreclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical...
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Primary tumor resection or systemic treatment as palliative treatment for patients with isolated synchronous colorectal cancer peritoneal metastases in a nationwide cohort study
Limited data are available to guide the decision-making process for clinicians and their patients regarding palliative treatment options for patients...
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Does the degree of preoperative gait disturbance remain after tumor resection in patients with intradural extramedullary spinal cord tumors?
Study designRetrospective comparative study.
ObjectiveThis study aimed to determine whether the degree of preoperative gait disturbance remains...
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Hypofractionated stereotactic radiotherapy (HFSRT) versus single fraction stereotactic radiosurgery (SRS) to the resection cavity of brain metastases after surgical resection (SATURNUS): study protocol for a randomized phase III trial
BackgroundThe brain is a common site for cancer metastases. In case of large and/or symptomatic brain metastases, neurosurgical resection is...
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Radiological and surgical aspects of polymorphous low-grade neuroepithelial tumor of the young (PLNTY)
BackgroundPolymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a low-grade epilepsy-associated tumor recently introduced in WHO 2021...
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Visualization and Characterization of Glioma and Brain Activity to Maximize Safe Tumor Resection in Awake Surgery
Glioma is usually amenable to surgical treatment; the extent of resection (EOR) is significantly associated with prognosis in low- or high-grade...
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Outcomes of surgical resection and intraoperative electron radiotherapy for patients with para-aortic recurrences of gastrointestinal and gynecologic malignancies
BackgroundPara-aortic lymph node (PALN) metastases from primary pelvic malignancies are often treated with resection, but recurrence is common. We...
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Spatial and temporal heterogeneity of tumor immune microenvironment between primary tumor and brain metastases in NSCLC
BackgroundBrain metastasis is a common outcome in non-small cell lung cancer, and despite aggressive treatment, its clinical outcome is still...
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Association between primary tumor characteristics and histopathological growth pattern of liver metastases in colorectal cancer
Introduction: The microarchitecture of liver metastases (LMs), or histopathological growth pattern (HGP), has been demonstrated to be a significant...
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Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases
The liver is a common site for metastasis in colorectal cancer. Hepatectomy has emerged as the gold standard for the treatment of colorectal liver...
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A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors
The main goal of brain tumorBrain tumor surgerySurgery is to achieve gross total tumor resection without postoperative complicationsComplication and...
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Normalization of tumor markers and a clear resection margin affect progression-free survival of patients with unresectable pancreatic cancer who have undergone conversion surgery
BackgroundWith the advent of intensive combination regimens, an increasing number of patients with unresectable pancreatic cancer (UPC) have regained...
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Impact of preoperative white blood cell count on outcomes in different stage colorectal cancer patients undergoing surgical resection: a single-institution retrospective cohort study
PurposeTo explore the association between preoperative WBC count and the long-term survival outcomes and clinical outcomes in different stage...
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Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps
Surgery is unanimously regarded as the primary strategy to cure solid tumors in the early stages but is not always used in advanced cases. However,...
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Machine learning to improve interpretability of clinical, radiological and panel-based genomic data of glioma grade 4 patients undergoing surgical resection
BackgroundGlioma grade 4 (GG4) tumors, including astrocytoma IDH-mutant grade 4 and the astrocytoma IDH wt are the most common and aggressive primary...
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Persistent high levels of carcinoembryonic antigen after tumor resection are associated with poorer survival outcomes in patients with resected colon cancer
BackgroundInterindividual survival and recurrence rates in cases of locoregional colon cancer following surgical resection are highly variable. The...
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Overexpression of UTX promotes tumor progression in Oral tongue squamous cell carcinoma patients receiving surgical resection: a case control study
BackgroundUbiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been identified as a histone 3 lysine 27 (H3K27) demethylase...
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Surgical Therapy of Non-Skull Base Meningiomas
In a previous chapter, the surgical management of skull base meningiomas were discussed. However, the most common meningiomas that are diagnosed and...
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Exploring extracellular matrix and prostaglandin pathway alterations across varying resection margin distances of right-sided colonic adenocarcinoma
BackgroundSurgical resection followed by indicated adjuvant therapy offers potential curative treatment in colonic adenocarcinoma. Beyond the...
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Tumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis
BackgroundThe prognostic significance of tumor burden score (TBS) in relation to carcinoembryonic antigen (CEA) has not been investigated among...
