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Novel pyran derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity, and molecular modeling
Twenty-six novel pyran derivatives ( 1a−m , 2a−m ) were designed, synthesized, and characterized by IR, 1 H NMR, 13 C NMR, and HRMS. The crystal...
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Comprehensive overview of how to fade into succinate dehydrogenase dysregulation in cancer cells by naringenin-loaded chitosan nanoparticles
Mitochondrial respiration complexes play a crucial function. As a result, dysfunction or change is intimately associated with many different...
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Cancer-derived extracellular succinate: a driver of cancer metastasis
Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate...
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Design, synthesis, and antifungal activity evaluation of novel 2-cyano-5-oxopentanoic acid derivatives as potential succinate dehydrogenase inhibitors
Two series of novel 2-cyano-5-oxopentanoic acid derivatives ( 1a−l , 2a−l ) were designed, synthesized, and characterized by IR, 1 H NMR, 13 C NMR, and...
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Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol
The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight....
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Succinate dehydrogenase B-deficient renal cell carcinoma with a germline variant in a Japanese patient: a case report
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare renal cancer. A 75-year-old Japanese female presented with gross...
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The Study of the Effectiveness of Ethylmethylhydroxypyridine Succinate in Acute Alcohol Intoxication
The effectiveness of ethylmethylhydroxypyridine succinate (EMHPS) in acute alcohol intoxication was tested in a study on SPF male outbred ICR mice....
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Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate
BackgroundSuccinate is produced by both human cells and by gut bacteria and couples metabolism to inflammation as an extracellular signaling...
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CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening
BackgroundThe most common site of metastasis in colorectal cancer (CRC) is the liver and liver metastases occur in more than 50% of patients during...
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Activities of Succinate Dehydrogenase and Lactate Dehydrogenase in Blood Lymphocytes in Yakut Ground Squirrels Spermophilus undulatus During Hibernation and in the Active State
We studied energy metabolism in blood lymphocytes of Yakut ground squirrels Spermophilus undulatus in active state and during hibernation. Activities...
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Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages
Metabolic reprogramming is associated with NLRP3 inflammasome activation in activated macrophages, contributing to inflammatory responses. Tanshinone...
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Inhalable spray-dried porous microparticles containing dehydroandrographolide succinate phospholipid complex capable of improving and prolonging pulmonary anti-inflammatory efficacy in mice
Due to the unique physiological barriers within the lungs, there are considerable challenges in develo** drug delivery systems enabling prolonged...
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Impairment of electron transport chain and induction of apoptosis by chrysin nanoparticles targeting succinate-ubiquinone oxidoreductase in pancreatic and lung cancer cells
BackgroundFlavonoids may help ameliorate the incidence of the major causes of tumor-related mortality, such as pancreatic ductal adenocarcinoma...
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Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination
The metabolic needs of the premature/premyelinating oligodendrocytes (pre-OLs) and mature oligodendrocytes (OLs) are distinct. The metabolic control...
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Clinical features and ALDH5A1 gene findings in 13 Chinese cases with succinic semialdehyde dehydrogenase deficiency
Background and aimsTo investigate the clinical features, ALDH5A1 gene variations, treatment, and prognosis of patients with succinic semialdehyde...
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Neuroprotective mechanism of trans,trans-Farnesol in an ICV-STZ-induced rat model of Alzheimer’s pathology
BackgroundAlzheimer’s disease (AD) is a prominent cause of dementia, resulting in neurodegeneration and memory impairment. This condition imposes a...
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Current management of succinate dehydrogenase–deficient gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are increasingly recognized as having diverse biology. With the development of tyrosine kinase inhibitors...
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Sulfite Impairs Bioenergetics and Redox Status in Neonatal Rat Brain: Insights into the Early Neuropathophysiology of Isolated Sulfite Oxidase and Molybdenum Cofactor Deficiencies
AbstractIsolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies are genetic diseases biochemically characterized by the toxic...
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Novel insights into the glucose metabolic alterations of freshwater snails: a pathway to molluscicide innovation and snail control strategies
As ecosystem disruptors and intermediate hosts for various parasites, freshwater snails have significant socioeconomic impacts on human health,...
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Andrographolide and Its Derivative Potassium Dehydrographolide Succinate Suppress PRRSV Replication in Primary and Established Cells via Differential Mechanisms of Action
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause significant economic loss worldwide and remains a serious threat to...
