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Systemic therapy and radiotherapy related complications and subsequent hospitalisation rates: a systematic review
BackgroundHospitalisation resulting from complications of systemic therapy and radiotherapy places a substantial burden on the patient, society, and...
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Progression patterns, resistant mechanisms and subsequent therapy for ALK-positive NSCLC in the era of second-generation ALK-TKIs
BackgroundIn the era of second-generation ALK tyrosine kinase inhibitors (ALK-TKIs), there was a paucity of data regarding the progression patterns,...
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Arterial Stiffness May Predict Subsequent Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer Patients
Cancer therapy-related cardiac dysfunction (CTRCD) is still a serious problem. Existing risk scores are insufficient for risk classification,...
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Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy
BackgroundThere is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent...
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Subsequent primary neoplasms after childhood cancer therapy – design and description of the German nested case–control study STATT-SCAR
BackgroundSubsequent primary neoplasms (SPN) are among the most severe late effects and the second most frequent cause of death in childhood cancer...
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Clinical evidence for immune-based strategies in early-line multiple myeloma: current challenges in decision-making for subsequent therapy
Almost all patients with multiple myeloma (MM) will eventually develop disease that has relapsed with or become refractory to available treatments...
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Outcomes in men with metastatic castration-resistant prostate cancer who received sipuleucel-T and no immediate subsequent therapy: experience at Dana Farber and in the PROCEED Registry
BackgroundSipuleucel-T has demonstrated survival benefit in phase 3 trials but is utilized in few men with metastatic castration-resistant prostate...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Nanoparticles in Cancer Therapy
In the realm of cancer therapy, nanoparticles have emerged as a pioneering avenue, ushering in a remarkable journey filled with breakthroughs and...
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Nanoparticle-Mediated Radiation Therapy
Radiation therapy mediated by nanoparticles is a new and exciting area in cancer treatment that offers creative ways to maximize the therapeutic...
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Development of a risk prediction model for subsequent infection after colonization with carbapenem-resistant Enterobacterales: a retrospective cohort study
BackgroundColonization of carbapenem-resistant Enterobacterale (CRE) is considered as one of vital preconditions for infection, with corresponding...
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Cancer Therapy
Current cancer therapy is based on surgery, radiotherapy, chemotherapy, and immunotherapy, often administered in combination. Cytotoxic chemotherapy...
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Hormone Therapy for Advanced Prostate Cancer
The identification of probable sources of androgen and strategies for lowering their levels are essential to the characterization of advanced PC. The...
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Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors
Survivors of childhood cancer are at increased risk for subsequent cancers attributable to the late effects of radiotherapy and other treatment...
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Exposure Therapy and Its Mechanisms
Exposure therapy is the gold-standard treatment approach for pathological anxiety. This therapeutic approach builds on principles of extinction...
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Monitoring of Antiplatelet Therapy
In the late 1990s, the antithrombotic antiplatelet agent, clopidogrel, a P2Y12 inhibitor, was introduced. Around the same time, there was an increase...
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Cost and Insurance Issues in Botulinum Toxin Therapy
Botulinum toxin therapy is now an established mode of treatment for a large number of medical problems. It is FDA approved for treatment of migraine,...
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Therapy-related clonal cytopenia as a precursor to therapy-related myeloid neoplasms
Therapy-related myeloid neoplasms (t-MN) are aggressive leukemia that develops as a complication of prior exposure to DNA-damaging agents. Clonal...
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Prospective approaches to gene therapy computational modeling – spotlight on viral gene therapy
Clinical studies have found there still exists a lack of gene therapy dose-toxicity and dose-efficacy data that causes gene therapy dose selection to...
