Search
Search Results
-
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking
BackgroundHuman angiotensin-converting enzyme 2 (ACE2), a type I transmembrane receptor physiologically acting as a carboxypeptidase enzyme within...
-
Subcellular localization and interactions among TGB proteins of cowpea mild mottle virus
Cowpea mild mottle virus (CPMMV) is a flexuous filamentous virus that belongs to the genus Carlavirus (family Betaflexiviridae ). The CPMMV genome...
-
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). The most common mutation,...
-
Phylogenetic trees, conserved motifs and predicted subcellular localization for transcription factor families in pearl millet
ObjectivesPearl millet ( Pennisetum glaucum ) is a cereal crop that is tolerant to a high temperature, a drought and a nutrient-poor condition....
-
Subcellular and Synaptic Distribution of Muscarinic Receptors in Neurons by Confocal and Electron Microscopy
The function of a G protein-coupled receptor in the modulation of neuronal activity is highly dependent on its availability at the cell surface, its...
-
Augmented sequence features and subcellular localization for functional characterization of unknown protein sequences
Advances in high-throughput techniques lead to evolving a large number of unknown protein sequences (UPS). Functional characterization of UPS is...
-
Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness
BackgroundThe Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in...
-
The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein’s subcellular localization, palmitoylation and pseudovirus entry
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein determines virus entry and the palmitoylation of S protein...
-
Subcellular localization of D2 receptors in the murine substantia nigra
G-protein-coupled D2 autoreceptors expressed on dopamine neurons (D2Rs) inhibit transmitter release and cell firing at axonal endings and...
-
Massively parallel identification of mRNA localization elements in primary cortical neurons
Cells adopt highly polarized shapes and form distinct subcellular compartments in many cases due to the localization of many mRNAs to specific areas,...
-
Cellular and subcellular localization of endogenous phospholipase D6 in seminiferous tubules of mouse testes
Phospholipase D6 (PLD6) plays pivotal roles in mitochondrial dynamics and spermatogenesis, but the cellular and subcellular localization of...
-
Real-Time Quantitative PCR and Fluorescence In Situ Hybridization for Subcellular Localization of miRNAs in Neurons
Neuronal miRNAs play major roles in regulation of synaptic development and plasticity. The small size of miRNAs and, in some cases, their low level...
-
The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal
BackgroundMerkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC...
-
Self-evoluting framework of deep convolutional neural network for multilocus protein subcellular localization
In the present paper, deep convolutional neural network (DCNN) is applied to multilocus protein subcellular localization as it is more suitable for...
-
Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing
Technology for spatial multi-omics aids the discovery of new insights into cellular functions and disease mechanisms. Here we report the development...
-
Generalized nuclear localization of retroelement transcripts
BackgroundLINE-1s, Alus and SVAs are the only retrotransposition competent elements in humans. Their mobilization followed by insertional mutagenesis...
-
Subcellular localization of the porcine deltacoronavirus nucleocapsid protein
Porcine deltacoronavirus (PDCoV) has been recently identified as an emerging enteropathogenic coronavirus that mainly infects newborn piglets and...
-
A Simple Method for Visual Assessment and Quantification of Altered Subcellular Localization of Nuclear Receptors
All nuclear receptors reside in the nuclear compartment when transcriptionally active. However, their subcellular localization can vary when...
-
Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity
The intercalated cell Cl − /HCO 3 − exchanger, pendrin, modulates ENaC subunit abundance and function. Whether ENaC modulates pendrin abundance and...
-
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization
BackgroundRNA binding proteins (RBPs)—regulated gene expression play a vital role in various pathological processes, including the progression of...
