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Spectrofluorimetric Protocol for Estimation of Commonly Used Antispasmodic Drotaverine. Fluorescence Quenching Study
A fast, simple, accurate, precise, and cheap fluorimetric protocol has been proposed for analysis of a phosphodiesterase-IV inhibitor, namely...
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An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
BackgroundInduced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease....
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Elements of Clinical Trial Protocol Design
Clinical trials are conducted for many reasons, including to determine whether a new drug is safe and effective for a therapeutic use. A clinical... -
Randomized controlled phase III trial to investigate superiority of robot-assisted gastrectomy over laparoscopic gastrectomy for clinical stage T1-4aN0-3 gastric cancer patients (JCOG1907, MONA LISA study): a study protocol
BackgroundLaparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks,...
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Process evaluation protocol plan for a home-based physical activity intervention versus educational intervention for persistent taxane-induced peripheral neuropathy (B-HAPI study): a randomized controlled trial
BackgroundEvaluation publications typically summarize the results of studies to demonstrate the effectiveness of an intervention, but little is...
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Protocol to Study West Nile Virus Infection in Brain Slices In Vitro
Ex vivo slice cultures of the brain tissue can maintain the cytoarchitecture of the central nervous system (CNS), which allows a thorough... -
Priming constraint-induced movement therapy with intermittent theta burst stimulation to enhance upper extremity recovery in patients with stroke: protocol for a randomized controlled study
BackgroundThe treatments based on motor control and motor learning principles have gained popularity in the last 20 years, as well as non-invasive...
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The effect of physical exercise during radiotherapy on physical performance in patients with head and neck cancer: a trial within cohorts study protocol, the vital study
BackgroundDuring the last decade, twelve studies have been published investigating physical exercise interventions (PEIs) in patients with head and...
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The Implementation of an Integrated Oral Care Protocol for Pediatric Cancer Patients: a Qualitative Study
AimIn this study, we evaluated the impact of an integrated oral care protocol for pediatric patients undergoing antineoplastic treatment from the...
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HPV testing in Polish population-based cervical cancer screening programme (HIPPO project)—study protocol of a randomised healthcare policy trial
BackgroundAn Organised Cervical Cancer Screening Programme (OCCSP) was started in Poland in 2006/2007. Each woman aged 25 to 59 is eligible for a...
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Protocol of the RACB study: a multicenter, single-arm, prospective study to evaluate the efficacy of resection of initially unresectable hepatocellular carcinoma with atezolizumab combined with bevacizumab
BackgroundAlthough the standard therapy for advanced-stage hepatocellular carcinoma (HCC) is systemic chemotherapy, the combination of atezolizumab...
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Multidisciplinary treatment protocol for ischiatic, sacral, trochanteric or other pressure injuries in people with spinal cord injury: a retrospective cohort study
Study designRetrospective cohort study Objectives: to describe the incidence and the associated risk factors of post-surgical complications and...
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Personalised exercise rehabilitation in cancer survivorship: the percs triage and referral system study protocol
BackgroundTo effectively embed exercise rehabilitation in cancer survivorship care, a co-ordinated system of acute and community exercise...
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Using antenatal care as a platform for malaria surveillance data collection: study protocol
BackgroundWhile many malaria-endemic countries have health management information systems that can measure and report malaria trends in a timely...
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Vaginal CO2 laser therapy for genitourinary syndrome in breast cancer survivors—VagLaser study protocol: a randomized blinded, placebo-controlled trial
BackgroundVaginal CO 2 laser therapy is a new treatment option for genitourinary syndrome of menopause. Its potential is particularly interesting in...
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The Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties
This study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic...
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Exploring long-term cancer survivors’ care experiences and unmet needs: protocol for a qualitative study
BackgroundThe number of cancer survivors has increased in recent decades, and the majority of them suffer from sequelae of their disease and...
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An electrical stimulation intervention protocol to prevent disuse atrophy and muscle strength decline: an experimental study in rat
BackgroundSkeletal muscle is negatively impacted by conditions such as spaceflight or prolonged bed rest, resulting in a dramatic decline in muscle...
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Study protocol: fish oil supplement in prevention of oxaliplatin-induced peripheral neuropathy in adjuvant colorectal cancer patients – a randomized controlled trial. (OxaNeuro)
BackgroundOxaliplatin-induced peripheral neuropathy (OIPN) in general and painful OIPN in particular is a debilitating late effect that severely...
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Preoperative chemoradiotherapy using tegafur/uracil, oral leucovorin, and irinotecan (TEGAFIRI) followed by oxaliplatin-based chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: the study protocol for a phase II trial
BackgroundTotal neoadjuvant therapy (TNT) is a novel treatment strategy that is an alternative to preoperative chemoradiotherapy (CRT) for locally...