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1. Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

   Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (T _H 2) immune cell response...

   **a Zhu, Ji-Ye Huang, ... Zhi Zhang in Nature Neuroscience

   Article 30 January 2024
   

2. Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection

   Objective

   The objective of this study was to investigate the correlation between spleen density and the prognostic outcomes of patients who underwent...

   Yunzhou **ao, **aoting Wen, ... Shouliang Miao in BMC Cancer

   Article Open access 06 April 2024
   

3. Features of Spleen Development in Newborn Rats Exposed to Endocrine Disrupter Dichlorodiphenyltrichloroethane during the Prenatal Period

   The development of the spleen in newborn male Wistar rats exposed to low-dose endocrine disruptor dichlorodiphenyltrichloroethane during the prenatal...

   N. V. Yaglova, B. B. Gagulaeva, ... V. V. Yaglov in Bulletin of Experimental Biology and Medicine

   Article 01 November 2023

4. The spleen is the graveyard of CD4+ cells in patients with immunological failure of visceral leishmaniasis and AIDS

   Background

   Visceral leishmaniasis (VL), or kala-azar, is a common comorbidity in patients with AIDS in endemic areas. Many patients continue to...

   Luis Gustavo Cavalcante Reinaldo, Raimundo José Cunha Araújo Júnior, ... Carlos Henrique Nery Costa in Parasites & Vectors

   Article Open access 15 March 2024
   

5. Standardization of DNA extraction from paraffinized spleen samples: molecular diagnosis of human malaria

   Background

   Plasmodium vivax is the main species responsible for human malaria in Brazil, and one of its manifestations is splenic malaria, though...

   Raimunda Sandra Pacheco Souza, Monique F. dos Reis, ... Marcus Vinicius Guimaraes de Lacerda in Malaria Journal

   Article Open access 27 November 2023
   

6. Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation

   Background

   The noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of...

   Ibrahim T. Mughrabi, Michael Gerber, ... Stavros Zanos in Journal of Neuroinflammation

   Article Open access 17 October 2023
   

7. Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function

   Background

   Inflammation is a fundamental biological response to injury and infection, which if unregulated can contribute to the pathophysiology of...

   Nobuhide Kobori, Anthony N. Moore, ... Pramod K. Dash in Journal of Neuroinflammation

   Article Open access 04 July 2023
   

8. The Rarity of Metastasis to the Spleen — a Phenomenon with an Unknown Mechanism

   The review analyses the frequency of malignant tumors metastasizing to the spleen. The facts are presented of a higher frequency of metastasis to the...

   E. S. Andryukhova, L. A. Tashireva, ... V. M. Perelmuter in Bulletin of Experimental Biology and Medicine

   Article 01 September 2022

9. Tannic acid may ameliorate doxorubicin-induced changes in oxidative stress parameters in rat spleen

   Doxorubicin (DOX) is a potent and broad-spectrum drug widely used in the treatment of cancer. However, the toxicity and side effects of DOX on...

   Duygu Kizir, Melike Karaman, Hamid Ceylan in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 05 June 2023
   

10. MRI-based inter- and intrafraction motion analysis of the pancreatic tail and spleen as preparation for adaptive MRI-guided radiotherapy in neuroblastoma

    Background

    In pediatric radiotherapy treatment planning of abdominal tumors, dose constraints to the pancreatic tail/spleen are applied to reduce late...

    Fasco Van Ommen, Gaelle A.T. le Quellenec, ... Geert O. Janssens in Radiation Oncology

    Article Open access 02 October 2023
    

11. FACS to Identify Immune Subsets in Mouse Brain and Spleen

    Flow cytometry enables the multi-parametric quantification of cell types, especially in immunophenoty** of unique immune cell subsets that can...

    Mary K. Malone, Thomas A. Ujas, ... Ann M. Stowe in Neural Repair

    Protocol 2023
    

12. Bulk RNA-seq Assessment of Murine Spleen Using a Portable MinION Sequencing Device

    Comprehensive profiling of the transcriptome reflects the dynamic changes in complex regulator interactions between genes and proteins in the...

    Yasuyuki Suzuki, Shuang Liu in Rheumatoid Arthritis

    Protocol 2024
    

13. Effects of hyperventilation on oxygenation, apnea breaking points, diving response, and spleen contraction during serial static apneas

    Purpose

    Hyperventilation is considered a major risk factor for hypoxic blackout during breath-hold diving, as it delays the apnea breaking point....

    Frank Pernett, Pontus Bergenhed, ... Erika Schagatay in European Journal of Applied Physiology

    Article Open access 15 April 2023
    

14. Identification and protective role of CD34⁺ stromal cells/telocytes in experimental autoimmune encephalomyelitis (EAE) mouse spleen

    Experimental autoimmune encephalomyelitis (EAE) is a classical animal model of human multiple sclerosis (MS) that is most commonly used to study the...

    Ganesh Dama, **aoxi Hu, ... Juntang Lin in Histochemistry and Cell Biology

    Article 04 April 2023
    

15. The role of spleen volume change in predicting immunotherapy response in metastatic renal cell carcinoma

    Introduction

    Resistance to immune checkpoint inhibitors (ICI) is a significant issue in metastatic renal cell carcinoma (mRCC), as it is in the...

    Volkan Aslan, Atiye Cenay Karabörk Kılıç, ... Nuriye Özdemir in BMC Cancer

    Article Open access 30 October 2023
    

16. Discovery of highly immunogenic spleen-resident FCGR3⁺CD103⁺ cDC1s differentiated by IL-33-primed ST2⁺ basophils

    Recombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed immunological mechanism is still unknown. IL-33-mediated tumor suppression...

    Myeong-Ho Kang, JungHyub Hong, ... Yong-Soo Bae in Cellular & Molecular Immunology

    Article Open access 29 May 2023
    

17. Dynamics of Changes in the cAMP/cGMP Concentration Ratio in the Thymus and Spleen of Laboratory Mice during Vaccination against Plague and Tularemia against the Background of Immunomodulation

    Vaccine strains Yersinia pestis EV NIIEG at a dose of 10 ³ CFU and Francisella tularensis 15 NIIEG at a dose of 10 ² CFU induced changes in the...

    V. I. Dubrovina, O. V. Yur’eva, ... S. V. Balakhonov in Bulletin of Experimental Biology and Medicine

    Article 01 February 2024

18. A Spleen Tyrosine Kinase’s Sky in Neuronal Degeneration

    Wan-Yun Zhang, Sen Lin in Neuroscience Bulletin

    Article 03 November 2023
    

19. Atazanavir-Concentrate Loaded Soft Gelatin Capsule for Enhanced Concentration in Plasma, Brain, Spleen, and Lymphatics

    This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration...

    Sheshank Sethi, Vikas Rana in AAPS PharmSciTech

    Article 28 September 2022
    

20. RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis

    Background

    Toxocara canis is a cosmopolitan parasite with a significant adverse impact on the health of humans and animals. The spleen is a major...

    Yue Xu, Wen-Bin Zheng, ... Hany M. Elsheikha in Parasites & Vectors

    Article Open access 04 August 2022