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Survey of attitude to human genome modification in Nigeria
Gene editing and mitochondrial replacement therapy (MRT) are biotechnologies used to modify the host nuclear and mitochondrial DNA, respectively....
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Pan-cancer atlas of somatic core and linker histone mutations
Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the...
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Somatic genetic variation in healthy tissue and non-cancer diseases
Somatic genetic variants have been studied for several years mostly concerning cancer, where they contribute to its origin and development. It is...
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What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?
Acidosis is a chemical signature of the tumour microenvironment that challenges intracellular pH homeostasis. The orchestrated activity of acid-base...
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Lactylation: the novel histone modification influence on gene expression, protein function, and disease
Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in scientific interest since...
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RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential
Head and neck squamous cell carcinoma ranks seventh in incidence of malignant tumours in the world. Although there are treatments including surgery,...
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Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers
The most frequent special histological type of breast cancer is represented by invasive lobular carcinoma (ILC), which makes up about 15% of all...
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Looking ahead: ethical and social challenges of somatic gene therapy for sickle cell disease in Africa
Somatic gene therapy will be one of the most exciting practices of genetic medicine in Africa and is primed to offer a “new life” for persons living...
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Comprehensive analysis of m6A modification in immune infiltration, metabolism and drug resistance in hepatocellular carcinoma
N6-methyladenosine (m6A) is important in regulating mRNA stability, splicing, and translation, and it also contributes to tumor development. However,...
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Epigenetic Modification in Aluminum-Induced Neurotoxicity
The toxicity of aluminum has been confirmed from many aspects, such as plant, animal, model organism, in vitro study, and epidemiological studies....
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A cellular model provides insights into the pathogenicity of the oncogenic FOXL2 somatic variant p.Cys134Trp
BackgroundFOXL2 is a transcription factor expressed in ovarian granulosa cells. A somatic variant of FOXL2 (c.402 C > G, p.Cys134Trp) is the...
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Genetic variants in m5C modification genes are associated with survival of patients with HBV-related hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a high mortality rate. The 5-methylcytosine (m5C), a type of RNA...
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N6-methyladenosine methylation modification patterns reveal immune profiling in pancreatic adenocarcinoma
BackgroundSeveral studies have revealed that N6-methyladenosine (m6A) regulation is involved in various biological processes and cancer progression....
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Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer
The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has...
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Visualizing histone H4K20me1 in knock-in mice expressing the mCherry-tagged modification-specific intracellular antibody
During development and differentiation, histone modifications dynamically change locally and globally, associated with transcriptional regulation,...
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8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic...
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RNA modification: mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA that are regulated by specific modifying enzymes. They play...
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Biological roles of the RNA m6A modification and its implications in cancer
The N 6 -Methyladenosine (m 6 A) modification of RNA transcripts is the most prevalent and abundant internal modification in eukaryotic messenger RNAs...
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Emotions Studied by Imaging of the Human Brain: The Somatic and Emotional Motor Systems
The brain has only two goals, survival of the individual and survival of the species. One of the most important tools to accomplish these goals is...
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SAHA Inhibits Somatic Hyperalgesia Induced by Stress Combined with Orofacial Inflammation Through Targeting Different Spinal 5-HT Receptor Subtypes
Epigenetic regulation of gene expression has been implicated in the development of chronic pain. However, little is known about whether this...
