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Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD
BackgroundIn neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils...
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Differential acute-phase protein responses in dogs seropositive or seronegative for Neospora caninum
Neospora caninum is one of the most prevalent Apicomplexa parasites that causes abortion in cattle, as it infects dogs as its definitive host,...
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Plasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population
ObjectivePlasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC...
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Enhancement of Zika virus infection by antibodies from West Nile virus seropositive individuals with no history of clinical infection
BackgroundRecent outbreaks of Zika Virus (ZIKV) infection and associated microcephaly has raised multiple scientific questions. The close antigenic...
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Household and individual level risk factors associated with declining malaria incidence in Meghalaya, India: implications for malaria elimination in low-endemic settings
BackgroundA detailed analysis of household and individual level Plasmodium infection patterns in two low-endemic districts of Meghalaya was...
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Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses
PurposeThe human antibody repertoire forms in response to infections, the microbiome, vaccinations, and environmental exposures. The specificity of...
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Human Trypanosoma cruzi infection in the Argentinean Chaco: risk factors and identification of households with infected children for treatment
BackgroundChagas disease is a neglected tropical disease (NTD). Cost-effective strategies for large-scale implementation of diagnosis and etiological...
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Gut microbiota differences induced by Toxoplasma gondii seropositivity in stray cats in South Korea
T. gondii is a highly prevalent parasite worldwide, with cats serving as its final host. However, few studies have investigated the impact of T. gondii ...
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The choice of reference chart affects the strength of the association between malaria in pregnancy and small for gestational age: an individual participant data meta-analysis comparing the Intergrowth-21 with a Tanzanian birthweight chart
BackgroundThe prevalence of small for gestational age (SGA) may vary depending on the chosen weight-for-gestational-age reference chart. An...
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SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study
It is well established that neurological and non-neurological autoimmune disorders can be triggered by viral infections. It remains unclear whether...
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Epstein–Barr virus (EBV) antibody changes over time in a general population cohort in rural Uganda, 1992–2008
BackgroundEpstein–Barr virus (EBV) infection is ubiquitous and in sub-Saharan Africa, occurs early in life. In a population-based rural African...
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Prevalence and molecular characterization of Toxoplasma gondii in different types of poultry in Greece, associated risk factors and co-existence with Eimeria spp.
Toxoplasma gondii is a protozoan parasite of public health importance, infecting all warm-blooded animals, including chickens. Undercooked chicken...
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Serological and molecular detection of Toxoplasma gondii and Neospora caninum in free-ranging rats from Nagpur, India
Toxoplasma gondii and Neospora caninum are cyst-forming coccidian parasites that infect both wild and domestic non-felids as intermediate hosts, with...
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Microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of HIV-1-associated neurocognitive and affective alterations
Microglia, which are productively infected by HIV-1, are critical for brain development and maturation, as well as synaptic plasticity. The...
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Cognitive Intra-individual Variability in HIV: an Integrative Review
Nearly 30–50% of people living with HIV experience HIV-Associated Neurocognitive Disorder (HAND). HAND indicates performance at least one standard...
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Autoantibody-Mediated Depletion of IL-1RA in Still’s Disease and Potential Impact of IL-1 Targeting Therapies
BackgroundAdult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) resemble a continuum of a rare, polygenic IL-1β-driven...
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Autoantibodies to heat shock protein 60, 70, and 90 are not altered in the anti-SARS-CoV-2 IgG-seropositive humans without or with mild symptoms
Highly conserved heat shock proteins (Hsps) are localized in the cytoplasm and cellular organelles, and act as molecular chaperones or proteases....
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One health approach to toxocariasis in quilombola communities of southern Brazil
BackgroundToxocariasis has been listed among the most neglected parasitic diseases worldwide, with approximately one fifth of the global population...
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Using serological diagnostics to characterize remaining high-incidence pockets of malaria in forest-fringe Cambodia
BackgroundOver the last decades, the number of malaria cases has drastically reduced in Cambodia. As the overall prevalence of malaria in Cambodia...
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Proteomic profiles of major serum proteins in seropositive NMO patients alter after Rituximab treatment
Devic’s disease or neuromyelitis optica is an autoimmune inflammatory disease of the central nervous system that primarily affects the brain and...
