Search
Search Results
-
Skp2 modulates proliferation, senescence and tumorigenesis of glioma
BackgroundGliomas represent the largest class of primary central nervous system neoplasms, many subtypes of which exhibit poor prognoses. Surgery...
-
E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities
BackgroundHuman malignancies are composed of heterogeneous subpopulations of cancer cells with phenotypic and functional diversity. Among them, a...
-
AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
BackgroundGlioblastoma (GBM) is the most common brain tumor with the worst prognosis. Temozolomide is the only first-line drug for GBM....
-
Targeting SCF E3 Ligases for Cancer Therapies
SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for the degradation of proteins in a strictly regulated manner, through...
-
Outranking Decision-Making Method with Z-Number Cognitive Information
The Z-number provides an adequate and reliable description of cognitive information. The nature of Z-numbers is complex, however, and important...
-
Roles of F-box proteins in cancer
F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple...
-
Acquisition of epithelial–mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells
Background:Breast cancer is the most common female malignant disease, and the second leading cause of cancer-related death in the United States....
-
Spatial distribution of postotic crest cells defines the head/trunk interface of the vertebrate body: embryological interpretation of peripheral nerve morphology and evolution of the vertebrate head
The migration pathways and spatial distribution of neural crest cells largely depend on the embryonic architecture. At the preotic level in the...
-
The Transport Carrier Principle
The transport of metabolites across the intestinal epithelium has been a subject of absorbing interest to physiologists and pharmacologists for over...