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Two peptides derivate from Acinetobacter baumannii outer membrane protein K as vaccine candidates: a comprehensive in silico study
BackgroundThe lack of appropriate vaccines is an obstacle to the effective management of A. baumannii infections. Peptide vaccines offer an...
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Bioinformatics Databases and Tools Available for the Development of Antiviral Drugs
Viruses are responsible for spreading diseases and severe threats to humankind. Emerging viruses and their enigmatic genomic mutations are a serious...
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The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination
BackgroundThe immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and...
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Immunopeptidome mining reveals a novel ERS-induced target in T1D
Autoreactive CD8 + T cells play a key role in type 1 diabetes (T1D), but the antigen spectrum that activates autoreactive CD8 + T cells remains...
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Computational identification and characterization of antigenic properties of Rv3899c of Mycobacterium tuberculosis and its interaction with human leukocyte antigen (HLA)
A rise in drug-resistant tuberculosis (TB) cases demands continued efforts towards the discovery and development of drugs and vaccines. Secretory...
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In silico analysis of epitope-based CadF vaccine design against Campylobacter jejuni
ObjectiveVaccination is an important strategy for the eradication of infectious diseases. CadF protein of Campylobacter jejuni is one of the...
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Prediction and Identification of Epitopes in the Emy162 Antigen of Echinococcus multilocularis
IntroductionAlveolar echinococcosis (AE) is a zoonotic disease caused by the parasitism of Echinococcus multilocularis larvae in the intermediate...
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SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines,...
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An Immunoinformatics Approach in Design of Synthetic Peptide Vaccine Against Influenza Virus
Peptide-based vaccines are an appealing strategy which involves usage of short synthetic peptides to engineer a highly targeted immune response....
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Prediction and identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from endocan
BackgroundPrediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development...
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ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease
Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans -sialidase (TS) antigens either in the form of recombinant protein, encoded in...
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A novel neoantigen discovery approach based on chromatin high order conformation
BackgroundHigh-throughput sequencing technology has yielded reliable and ultra-fast sequencing for DNA and RNA. For tumor cells of cancer patients,...
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Immunoinformatics and Epitope Prediction
With advancements in sequencing technologies, vast amount of experimental data has accumulated. Due to rapid progress in the development of...
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Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of...
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Reverse Vaccinology and Its Applications
The application of the fields of pharmacogenomics and pharmacogenetics to vaccine design, profoundly combined with bioinformatics, has been recently...
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Identification of MHC Ligands and Establishing MHC Class I Peptide Motifs
MHC class I peptide motifs are used on a regular basis to identify and predict MHC class I ligands and CD8+ T cell epitopes. This approach is above...
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Mining Trypanosoma cruzi Genome Sequences for Antigen Discovery and Vaccine Development
A large number of studies have demonstrated that Trypanosoma cruzi can be controlled by vaccines in animal models, but the identification of...
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In Silico Designing of Vaccines: Methods, Tools, and Their Limitations
In the post genomic era, the finding of new therapeutic targets has hugely been accelerated by the use of bioinformatics tools. The availability of...
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Genome-Based Bioinformatic Prediction of Major Histocompatibility (MHC)
Over the last 17 years, a large amount of knowledge has been accumulated on various aspects of major histocompatibility complex (MHC) molecules. In...
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The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
Recent advances in neoantigen research have accelerated the development of tumor immunotherapies, including adoptive cell therapies (ACTs), cancer...
