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Survival outcomes in locally advanced dMMR rectal cancer: surgery plus adjunctive treatment vs. surgery alone
BackgroundRecent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse...
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The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery
BackgroundThe impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus,...
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Association of levels of metabolites with the safe margin of rectal cancer surgery: a metabolomics study
BackgroundRectal cancer is one of the most lethal of gastrointestinal malignancies. Metabonomics has gradually developed as a convenient, inexpensive...
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Does transanal drainage tubes placement have an impact on the incidence of anastomotic leakage after rectal cancer surgery? a systematic review and meta-analysis
BackgroundWhether Transanal drainage tubes (TDTs) placement reduces the occurrence of anastomotic leakage (AL) after rectal cancer (RC) surgery...
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PTEN and P-4E-BP1 might be associated with postoperative recurrence of rectal cancer patients undergoing concurrent radiochemotherapy
BackgroundLocal recurrence after surgery and radiochemotherapy seriously affects the prognosis of locally advanced rectal cancer (LARC) patients....
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ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy
Radiotherapy is one of the most common cancer treatments, yet, some patients require high doses to respond. Therefore, the development of new...
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Preoperative chemoradiotherapy induces multiple pathways related to anti-tumour immunity in rectal cancer
BackgroundRectal cancer treated with preoperative radiotherapy (RT) provides an interesting model to study changes induced on cancer cell...
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Research on radiotherapy related genes and prognostic target identification of rectal cancer based on multi-omics
BackgroundRadiosensitivity of rectal cancer is related to the radiotherapy efficacy and prognosis of patients with rectal cancer, and the genes and...
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Exploring treatment outcomes in Stage II-III rectal cancer patients undergoing neoadjuvant therapy at a tertiary care center in Pakistan: a comprehensive analysis of pathological outcomes
BackgroundRectal cancer treatment has transformed in recent years, with neoadjuvant treatment (NT) and total neoadjuvant treatment (TNT) aiming to...
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Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial
BackgroundThe early-onset rectal cancer with rapidly increasing incidence is considered to have distinct clinicopathological and molecular profiles...
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Protective ileostomy increased the incidence of rectal stenosis after anterior resection for rectal cancer
BackgroundIn most of the views, rectal stenosis after anterior resection for rectal cancer results from pelvic radiotherapy. However, patients...
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Is radiotherapy necessary for upper rectal cancer underwent curative resection? A retrospective study of 363 patients
BackgroundTo investigate the impact of radiotherapy (RT) on recurrence and survival in patients with locally advanced upper rectal cancer underwent...
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Colon and rectal cancer treatment patterns and their associations with clinical, sociodemographic and lifestyle characteristics: analysis of the Australian 45 and Up Study cohort
BackgroundColorectal cancer is the third most diagnosed cancer globally and the second leading cause of cancer death. We examined colon and rectal...
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Patients’ perspectives and the perceptions of healthcare providers in the treatment of early rectal cancer; a qualitative study
BackgroundShared decision-making has become of increased importance in choosing the most suitable treatment strategy for early rectal cancer,...
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Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer
The incidence of rectal cancer is increasing in patients younger than 50 years. Locally advanced rectal cancer is still treated with neoadjuvant...
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The clinical application of ctDNA to predict response to neoadjuvant chemoradiotherapy in patients with locally-advanced rectal cancer
Colorectal cancer is a major cause of cancer-related deaths worldwide. A third of colorectal cancers reside in the rectum. Many patients with rectal...
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Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer
BackgroundPreoperative chemoradiotherapy (CRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). We reported...
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Long-term outcomes of single-incision plus one-port laparoscopic surgery versus conventional laparoscopic surgery for rectosigmoid cancer: a randomized controlled trial
BackgroundThough our previous study has demonstrated that the single-incision plus one-port laparoscopic surgery (SILS + 1) is safe and feasible for...
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Can we use a simple blood test to reduce unnecessary adverse effects from radiotherapy by timely identification of radiotherapy-resistant rectal cancers? MeD-Seq rectal study protocol
BackgroundChemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced rectal cancer...
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A multi-centre randomized controlled trial investigating Consolidation Chemotherapy with and without oxaliplatin in distal rectal cancer and Watch & Wait
BackgroundNeoadjuvant chemoradiation(nCRT) has been considered the preferred initial treatment strategy for distal rectal cancer. Advantages of this...