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Autoradiography Assessment of Muscarinic Receptors in the Central Nervous System with a Special Focus on the Selectivity for M1 and M2 Muscarinic Receptors: Specific Protocol for M1 Muscarinic Receptors Labeling
The detection of muscarinic receptor binding sites is a crucial step in many experimental conditions. Despite radioligand binding to cell membranes...
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Muscarinic Receptor From Structure to Animal Models
This second edition volume expands on the previous edition with updated protocols on basic techniques of radioligand binding, allosteric modulation,...
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Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain
Neurotransmitter receptor densities are relevant for understanding the molecular architecture of brain regions. Quantitative in vitro receptor...
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Gradients of neurotransmitter receptor expression in the macaque cortex
Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization...
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Using Receptor Autoradiography to Visualize and Quantify Oxytocin and Vasopressin 1a Receptors in the Human and Nonhuman Primate Brain
Despite its development almost 40 years ago, receptor autoradiographyAutoradiography remains a regular and reliable practice for the localization of...
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Use of Antibodies in the Research on Muscarinic Receptor Subtypes
Antibodies can be a powerful tool to detect receptor expression at the protein level. Their main advantage is the potential of good spatial...
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Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase...
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A Novel Method to Estimate Levels of Receptors Using an Allosteric Modulator: Focus on Muscarinic M1 Receptor
This chapter outlines some of the general principles that need to be considered when develo** a radioligand binding assay to measure the affinity...
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Distribution of vasopressin 1a and oxytocin receptor protein and mRNA in the basal forebrain and midbrain of the spiny mouse (Acomys cahirinus)
The nonapeptide system modulates numerous social behaviors through oxytocin and vasopressin activation of the oxytocin receptor (OXTR) and...
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Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
P2X4 receptors are ATP-gated cation channels that were proposed as novel drug targets due to their role in inflammation and neuropathic pain. Only...
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Neurotransmitter and receptor systems in the subthalamic nucleus
The Subthalamic Nucleus (STh) is a lens-shaped subcortical structure located ventrally to the thalamus, that despite being embryologically derived...
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Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies
Affibodies targeting amyloid-beta (Aβ) could potentially be used as therapeutic and diagnostic agents in Alzheimer’s disease (AD). Affibodies display...
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Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target
Parkinson disease (PD) dementia, pathologically featured as nigrostriatal dopamine (DA) neuronal loss with motor and non-motor manifestations, leads...
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Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor–Receptor Interaction and Striatal Function
G protein-coupled receptors (GPCR) heterodimers represent new entities with unique pharmacological, signalling, and trafficking properties, with...
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The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1
Muscarinic acetylcholine receptors (mAChRs) have been shown to play significant roles in the regulation of normal cognitive processes in the...
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A Historical Perspective on the Dopamine D3 Receptor
Before 1990, the multiplicity of dopamine receptors beyond D1 and D2 had remained a controversial concept, despite its substantial clinical...
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Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis
APJ has been extensively described in the pathophysiology of angiogenesis and cell proliferation. The prognostic value of APJ overexpression in many...
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Receptor architecture of macaque and human early visual areas: not equal, but comparable
Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering...
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Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor
Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are frequently combined with medical psychostimulants such as methylphenidate...
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A new map of the rat isocortex and proisocortex: cytoarchitecture and M2 receptor distribution patterns
Neurotransmitters and their receptors are key molecules in information transfer between neurons, thus enabling inter-areal communication. Therefore,...
